55301-08-1

Upstream product

• 4530-20-5 BOC-glycine 
• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 
• 14296-92-5 (S)-1-(2-(tert-butoxycarbonylamino)acetyl)pyrrolidine-2-carboxylic acid 
• 29776-78-1 (S)-1-(2-tert-butoxycarbonylaminoacetyl)pyrrolidine-2-carboxylic acid benzyl ester 
• 66866-43-1 N-(t-butoxycarbonyl)glycyl i-butyl carbonate 
• 64472-24-8 glycyl-L-proline benzyl ester 
• 59191-07-0 glycyl-L-proline benzyl ester hydrochloride 

Downstream Products

• 118039-05-7 N-Boc-S-trityl-L-cysteinyl-glycyl-L-prolyl-glycyl-L-prolyl-S-trityl-L-cysteine benzhydryl ester 
• 118002-58-7 N-Boc-glycyl-L-prolyl-glycyl-L-prolyl-S-trityl-L-cysteine benzhydryl ester 
• 118002-59-8 glycyl-L-prolyl-glycyl-L-prolyl-S-trityl-L-cysteine benzhydryl ester 
• 118002-46-3 phenceptin 
• 1026191-35-4 Boc-Gly-Pro-Gly-Pro-Phe-Pro-Phe-Pro-OSu 
• 1026053-86-0 Boc-Gly-Pro-Gly-Pro-Phe-Pro-Phe-Pro-OBzl 
• 1026503-27-4 H-Gly-Pro-Gly-Pro-Phe-Pro-Phe-Pro-OSu 
• 149297-00-7 Boc-Gly-Pro-Gly-Pro-Phe-Pro-Phe-Pro-OH 

Relevant academic research and scientific papers

Structural-functional study of glycine-and-proline-containing peptides (Glyprolines) as potential neuroprotectors

A synthetic scheme for preparation of (Gly-Pro) n, (Pro-Gly) n (n = 2, 3), and (Pro-Gly-Pro) n (n = 1, 2) peptides was elaborated. The effect of the synthesized peptides and the Gly-Pro and Pro-Gly dipeptides on survival of cultured cells of PC12 rat pheochromocytoma was studied under the conditions of oxidative stress induced by brief incubation of the cells with hydrogen peroxide. Peptides of the general formula (Gly-Pro) n and the Pro-Gly-Pro peptide at a concentration of 0.2-100 μM were shown to decrease the number of damaged cells. The Gly-Pro peptide was the most active and decreased the number of damaged cells by 49% on average at a concentration of 100 μM.

Conformational studies of cyclo(L-Phe-L-Pro-Gly-L-Pro)2 by 1H- and 13C-nuclear magnetic resonance spectroscopy, and its enantioface-differentiating ability

Analyses of the 1H- and 13C-nuclear magnetic resonance (1H- and 13C-NMR) spectra of the cyclooctapeptide cyclo (L-Phe-L-Pro-Gly-L-Pro)2 (3) in CDCl3 with the aid of the C-H correlated spectroscopy (C-H COSY) two-dimensional NMR spectrum (Fig. 2) suggested that two kinds of C2-symmetric conformation with all trans and cis-trans-trans-trans forms coexist. When 0.5 eq of CsSCN or 1 eq of D- and L-PheOMe · HCl (D/L ratio = 1/2) was added to a solution of the cyclooctapeptide (3) in CDCl3, the 1H- and 13C-NMR spectra (Fig. 3) suggested the presence of only one C2-symmetric conformation (all trans), resulting from the formation of complexes with CsSCN or D- and L-PheOMe · HCl. The 13C-NMR spectra of the complexes of the cyclooctapeptide (3 or 4) with D- and L-PheOMe · HCl displayed separate resonances for each carbon atom of D-PheOMe · HCl and L-PheOMe · HCl. Furthermore, the ability of 3 to distinguish the D from the L enantiomer, is superior to that of 4 (Table II).