5531-70-4

Basic information

• Product Name: 2-(1-methyl-9H-carbazol-2-yl)ethanamine
• CAS NO: 5531-70-4
• Molecular Formula: C₁₅H₁₆N₂
• Molecular Weight: 224.3009
• Mol File: 5531-70-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 443.5°C at 760 mmHg
• Flash Point: 252.3°C
• Density: 1.188g/cm³
• Vapor Pressure: 4.62E-08mmHg at 25°C
• Refractive Index: 1.716
• CAS DataBase Reference: 2-(1-methyl-9H-carbazol-2-yl)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-methyl-9H-carbazol-2-yl)ethanamine(5531-70-4)
• EPA Substance Registry System: 2-(1-methyl-9H-carbazol-2-yl)ethanamine(5531-70-4)

Safety Data

• Hazardous Substances Data: 5531-70-4(Hazardous Substances Data)

Usage

Derivation

Carbazole

Usage

Medical research

Function

Selective agonist for the serotonin receptor

Target receptor subtype

5-HT2A

Additional affinity

5-HT2C and 5-HT2B receptor subtypes

Potential therapeutic effects

Depression, anxiety, and cognitive disorders

Note

Further research needed to understand mechanisms of action and potential applications.

Upstream product

• 100880-19-1 2-(1-methyl-9H-carbazol-2-yl)acetonitrile 
• 78061-54-8 N-benzoyl-2-(1-methyl-9H-carbazol-2-yl)ethylamine 
• 93009-07-5 ethyl 2-(1-oxo-2,3,4,9-tetrahydro-1H-carbazol-2-yl)-acetate 
• 92199-96-7 2-(1-oxo-2,3,4,9-tetrahydro-1H-carbazol-2-yl)acetic acid 
• 120-72-9 indole 
• 55854-93-8 (1-methyl-9H-carbazol-2-yl)methanol 
• 101283-44-7 1-Methyl-9H-carbazol-2-carbonsaeure-ethylester 
• 127472-68-8 r-2-(cyanomethyl)-1,2,3,4,t-4a,t-9a-hexahydro-c-1-methyl-t-3-(phenylsulfonyl)carbazole 
• 127472-67-7 r-1-methyl-3-(phenylsulfonyl)-1,4,t-4a,t-9a-tetrahydrocarbazole 
• 127472-69-9 r-2-(cyanomethyl)-1,2,3,4,t-4a,t-9a-hexahydro-c-1-methylcarbazole 

Downstream Products

• 61253-30-3 N-acetyl-2-(1-methyl-9H-carbazol-2-yl)ethylamine 
• 484-49-1 Guatambuinine 
• 4241-44-5 3,14-dihydroolivacine 

Relevant articles and documents

Total Synthesis of Olivacine and Ellipticine via a Lactone Ring-Opening and Aromatization Cascade

Effective preparation of olivacine and ellipticine via late-stage D-ring cyclization is described. Key features of the synthetic routes include trifluoroacetic acid-mediated formation of a lactone that is fused to a tetrahydrocarbazole derivative and its one-pot two-step ring opening and aromatization mediated by para-toluenesulfonic acid and palladium on carbon, respectively.

New Synthesis of the 6H-Pyridocarbazoles Ellipticine and Olivacine via Cycloaddition of 2-Phenylsulfonyl 1,3-Dienes to Indoles

An efficient synthesis of the antitumor alkaloids ellipticine and olivacine, starting from indole, was developed.The cycloaddition of 3-(phenylsulfonyl)-2,4-hexadiene or 2-(phenylsulfonyl)-1,3-pentadiene to the magnesium salt of indole was followed by C-C