61253-30-3Relevant articles and documents
Total Synthesis of Olivacine and Ellipticine via a Lactone Ring-Opening and Aromatization Cascade
Dilek, ?mer,Patir, Süleyman,Tilki, Tahir,Ertürk, Erkan
, p. 7901 - 7916 (2019/06/17)
Effective preparation of olivacine and ellipticine via late-stage D-ring cyclization is described. Key features of the synthetic routes include trifluoroacetic acid-mediated formation of a lactone that is fused to a tetrahydrocarbazole derivative and its one-pot two-step ring opening and aromatization mediated by para-toluenesulfonic acid and palladium on carbon, respectively.
New Synthesis of the 6H-Pyridocarbazoles Ellipticine and Olivacine via Cycloaddition of 2-Phenylsulfonyl 1,3-Dienes to Indoles
Baeckvall, Jan-E.,Plobeck, Niklas A.
, p. 4528 - 4531 (2007/10/02)
An efficient synthesis of the antitumor alkaloids ellipticine and olivacine, starting from indole, was developed.The cycloaddition of 3-(phenylsulfonyl)-2,4-hexadiene or 2-(phenylsulfonyl)-1,3-pentadiene to the magnesium salt of indole was followed by C-C
New Synthesis of Olivacine via a Heteroarylation Reaction
Naito, T.,Iida, N.,Ninomiya, I.
, p. 44 - 46 (2007/10/02)
The heteroarylation reaction between indole and 4-substituted pyridines under acylating conditions, followed by acidic cyclisation, provides a useful route to indole alkaloides, as exemplified by a new synthesis of olivacine.
