55323-56-3

Basic information

• Product Name: Benzeneethanol, 2-bromo-4-methoxy-5-(phenylmethoxy)-
• CAS NO: 55323-56-3
• Molecular Formula: C16H17BrO3
• Molecular Weight: 337.213
• Mol File: 55323-56-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzeneethanol, 2-bromo-4-methoxy-5-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneethanol, 2-bromo-4-methoxy-5-(phenylmethoxy)-(55323-56-3)
• EPA Substance Registry System: Benzeneethanol, 2-bromo-4-methoxy-5-(phenylmethoxy)-(55323-56-3)

Safety Data

• Hazardous Substances Data: 55323-56-3(Hazardous Substances Data)

Upstream product

• 2973-59-3 2-bromoisovanillin 
• 6451-86-1 5-benzyloxy-2-bromo-4-methoxybenzaldehyde 
• 697803-43-3 (E)-3-benzyloxy-6-bromo-4-methoxy-β-chlorostyrene 
• 621-59-0 isovanillin 
• 163595-81-1 5-benzyloxy-2-bromo-4,β-dimethoxystyrene 
• 697803-44-4 1-Benzyloxy-4-bromo-2-methoxy-5-vinyl-benzene 

Downstream Products

• 160857-70-5 (3-benzyloxy-6-bromo-4-methoxyphenethylimino)triphenylphosphorane 
• 160857-67-0 8-benzyloxy-5-bromo-7-methoxy-1-(3-nitro-4-methoxybenzyl)-3,4-dihydroisoquinoline 
• 158837-95-7 8-Benzyloxy-7-methoxy-1-(4-methoxy-3-nitro-benzyl)-3,4-dihydro-isoquinoline 
• 158837-97-9 1-(3-Azido-4-methoxy-benzyl)-8-benzyloxy-7-methoxy-3,4-dihydro-isoquinoline 
• 160857-66-9 5-bromo-8-benzyloxy-1-(3,4-dimethoxybenzyl)-7-methoxy-3,4-dihydroisoquinoline 
• 158837-99-1 8-Benzyloxy-1-(3,4-dimethoxy-benzyl)-7-methoxy-3,4-dihydro-isoquinoline 
• 158837-96-8 5-(8-Benzyloxy-7-methoxy-3,4-dihydro-isoquinolin-1-ylmethyl)-2-methoxy-phenylamine 
• 697803-46-6 1-(3,4-Dimethoxy-benzyl)-7-methoxy-3,4-dihydro-isoquinolin-8-ol 
• 479-39-0 (+)-cularine 
• 104420-84-0 (+)-Enneaphylline 

Relevant articles and documents

Diastereoselective Synthesis of Cularine Alkaloids via Enium Ions and an Easy Entry to Isoquinolines by Aza-Wittig Electrocyclic Ring Closure

In preliminary communications, we reported the diastereoselective synthesis of cularine and sarcocapnine via the intramolecular ring closure of nitrenium and oxenium ions, a new highly diastereoselective reductive methylation with (+)-8-phenylmenthyl chloroacetate followed by reduction with sodium borohydride, and a facile entry to the isoquinoline precursors by aza-Wittig electrocyclic ring closure. We now report the full details of the syntheses of (+)-O-demethylcularine, (+)-cularine, (+)-sarcocapnidine, (+)-sarcocapnine, and (+)-crassifoline and describe different methods of synthesis of their precursors.