55355-50-5

Upstream product

• 67-56-1 methanol 
• 32302-83-3 N-ε-benzyloxycarbonyl lysine 

Downstream Products

• 134915-79-0 6-Benzyloxycarbonylamino-2-{[1-(4-chloro-phenyl)-meth-(E)-ylidene]-amino}-hexanoic acid methyl ester 
• 27317-68-6 Boc-Lys(Z)-Lys(Z)-OMe 
• 134915-92-7 4-(4-Benzyloxycarbonylamino-butyl)-2-(1,5-bis-benzyloxycarbonylamino-pentyl)-4,5-dihydro-1H-imidazole-4-carboxylic acid methyl ester 
• 134915-82-5 methyl (RS)-2-amino-6-benzyloxycarbonylamino-2-phthalimidomethylhexanoate 
• 134915-85-8 methyl (RS)-2-amino-6-benzyloxycarbonylamino-2-aminomethylhexanoate 
• 37571-12-3 6-Benzyloxycarbonylamino-2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-hexanoic acid methyl ester 
• 86645-64-9 6-Benzyloxycarbonylamino-2-isobutoxycarbonylamino-hexanoic acid methyl ester 
• 1436-99-3 6-Benzyloxycarbonylamino-2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-hexanoic acid methyl ester 
• 23010-53-9 Boc-Ile-Lys(Z)-OMe 
• 33956-18-2 6-Benzyloxycarbonylamino-2-(2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-hexanoic acid methyl ester 
• 6367-62-0 N^α-Formyl-N^ε-benzyloxycarbonyl-lys-N^ε-benzyloxycarbonyl-lys-methylester 
• 36703-25-0 Formyl-leu-N^ε-benzyloxycarbonyl-lys 

Relevant academic research and scientific papers

Triple role of phenylselenonyl group enabled a one-pot synthesis of 1,3-oxazinan-2-ones from α-isocyanoacetates, phenyl vinyl selenones, and water

Reaction of α-substituted α-isocyanoacetates with phenyl vinyl selenones in the presence of a catalytic amount of base (DBU or Et3N, 0.05-0.1 equiv) followed by addition of p-toluenesulfonic acid (PTSA, 0.1-0.2 equiv) afforded 4,4,5-trisubstituted 1,3-oxazinan-2-ones in good to excellent yields. Enantiomerically enriched heterocycles can also be prepared using a Cinchona alkaloid-derived bifunctional organocatalyst for the Michael addition step. The phenylselenonyl group served as an activator for the Michael addition, a leaving group and a latent oxidant in this integrated reaction sequence.