55359-62-1Relevant academic research and scientific papers
Rhodium-catalyzed intramolecular hydroacylation of 1,2-disubstituted alkenes for the synthesis of 2-substituted indanones
Yuan, Jing,Liu, Chong,Chen, Yan,Zhang, Zhenfeng,Yan, Deyue,Zhang, Wanbin
, p. 269 - 277 (2018/12/05)
The intramolecular hydroacylation of 1,2-disubstituted alkenes was considered to be a challenging task due to the side reactions resulted from the lack of additional substituent at 1-position and the low activity caused by the steric hindrance of substituent at 2-position, and an asymmetric version has not been considered possible due to problems associated with the racemization of the products. We have partially solved these problems. Catalyzed by an activated diphosphine-Rh complex and reacted in a selected dihalogenated solvent, the intramolecular hydroacylation of o-(2-arylvinyl)benzaldehydes provided the corresponding 2-aryl-1-indanones in high yields, and its asymmetric variant using o-(2-alkylvinyl)benzaldehydes afforded chiral 2-alkyl-1-indanones in high yields and with moderate enantioselectivities.
The discovery of tetrahydrofluorenones as a new class of estrogen receptor β-subtype selective ligands
Wilkening,Ratcliffe,Tynebor,Wildonger,Fried,Hammond,Mosley,Fitzgerald,Sharma,McKeever,Nilsson,Carlquist,Thorsell,Locco,Katz,Frisch,Birzin,Wilkinson,Mitra,Cai,Hayes,Schaeffer,Rohrer
, p. 3489 - 3494 (2007/10/03)
Synthesis and derivatization of a series of substituted tetrahydrofluorenone analogs giving potent, ERβ subtype selective ligands are described. Several analogs possessing ERβ binding affinities comparable to 17β-estradiol but with greater than 75-fold selectivity over ERα are reported.
