55360-45-7

Upstream product

• 36282-40-3 (3-methoxyphenyl)magnesium bromide 
• 591-31-1 3-methoxy-benzaldehyde 
• 2398-37-0 3-methoxyphenyl bromide 
• 109-94-4 formic acid ethyl ester 
• 31600-88-1 m-methoxyphenyllithium 
• 124-38-9 carbon dioxide 
• 2845-89-8 1-chloro-3-methoxy-benzene 

Downstream Products

• 39193-85-6 3,3'-dimethoxybenzophenone 
• 112895-92-8 chlorobis(3-methoxyphenyl)methane 
• 189567-33-7 di(3-methoxyphenyl)methyl bromide 
• 1622071-23-1 C₁₇H₁₈O₄ 
• 112895-98-4 6-Methoxy-4-(3-methoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline 
• 112896-01-2 1-{6-(4-Chloro-butoxy)-4-[3-(4-chloro-butoxy)-phenyl]-3,4-dihydro-1H-isoquinolin-2-yl}-ethanone 
• 112895-99-5 1-[(R)-6-Methoxy-4-(3-methoxy-phenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-ethanone 
• 112896-00-1 1-[(R)-6-Hydroxy-4-(3-hydroxy-phenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-ethanone 
• 112965-88-5 (-)-6-methoxy-4-(3-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 112896-01-2 (-)-N-acetyl-6-(4-chlorobutoxy)-4-<3-(4-chlorobutoxy)phenyl>-1,2,3,4-tetrahydroisoquinoline 
• 113260-28-9 bis(3-methoxyphenyl)<(trimethylsily)oxy>acetonitrile 
• 112895-99-5 (-)-N-acetyl-6-methoxy-4-(3-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 112896-00-1 (-)-N-acetyl-6-hydroxy-4-(3-hydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 112895-98-4 6-Methoxy-4-(3-methoxy-phenyl)-1,2,3,4-tetrahydro-isoquinoline 

Relevant academic research and scientific papers

Photo-induced phosphorus radical involved semipinacol rearrangement reaction: Highly synthesis of γ-oxo-phosphonates

Hydroxyphosphoric acids display the unique biological activities, and they have some attractive prospects as clinical drug moleculars. Herein, a new approach for the synthesis of γ-oxo-phosphonates (the precursor of hydroxyphosphoric acid) has been established through the semipinacol rearrangement tactic involved the photo-induced phosphorus radical process. Most important, this transformation is avoid of the external oxidants, and occurs very well under the sunlight irradiation, meanwhile the γ-oxo-phosphonate was easily derivatized to obtain γ-hydroxyphosphoric acid, thus highlights the synthesis value of this method.

A Bisphenolic Honokiol Analog Outcompetes Oral Antimicrobial Agent Cetylpyridinium Chloride via a Membrane-Associated Mechanism

Targeting Streptococcus mutans is the primary focus in reducing dental caries, one of the most common maladies in the world. Previously, our groups discovered a potent bactericidal biaryl compound that was inspired by the natural product honokiol. Herein, a structure activity relationship (SAR) study to ascertain structural motifs key to inhibition is outlined. Furthermore, mechanism studies show that bacterial membrane disruption is central to the bacterial growth inhibition. During this process, it was discovered that analog C2 demonstrated a 4-fold better therapeutic index compared to the commercially available antimicrobial cetylpyridinium chloride (CPC) making it a viable alternative for oral care.

CoI-Catalyzed Barbier Reactions of Aromatic Halides with Aromatic Aldehydes and Imines

The reductive Barbier coupling of aromatic halides and electrophiles has been achieved using a CoBr2/1,10-phenanthroline catalytic system and over stoichiometric amounts of zinc. The reaction displayed a broad scope of substrates, including (hetero)aryl chlorides as pro-nucleophiles and aldehydes or imines as electrophiles, leading to diarylmethanols and diarylmethylamines in moderate to excellent yields, respectively.

Lewis Base Promoted Reduction of CO2 with BH3NH3 into Boryl Formates: CO2 as a Carbon Source in Organic Synthesis Under Mild Conditions

Lewis base promoted selective reduction of CO2 into boryl formates by using BH3NH3 as a reductant under mild conditions has been reported. The boryl formates, generated in situ, were shown to be reactive and versatile sources of formyl compounds to create new C–N, C–O, and C–C bonds. The reactivity of the boryl formates to yield formic acid, formamides, formates, secondary alcohols, and benzoheterocyclic rings was investigated.

UV light-mediated difunctionalization of alkenes through aroyl radical addition/1,4-/1,2-Aryl shift cascade reactions

UV light-mediated difunctionalization of alkenes through an aroyl radical addition/1,4-/1,2-aryl shift has been described. The resulted aroyl radical from a photocleavage reaction added to acrylamide compounds followed by cyclization led to the formation of oxindoles, whereas the addition to cinnamic amides aroused a unique 1,4-aryl shift reaction. Furthermore, the difunctionalization of alkenes of prop-2-en-1-ols was also achieved through aroyl radical addition and a sequential 1,2-aryl shift cascade reaction.

Visible light-mediated arylalkylation of allylic alcohols through concomitant 1,2-aryl migration

A photocatalytic process for selective arylalkylation of allylic alcohols with α-bromo diethyl malonate has been developed. The reaction provided a straightforward approach to synthesize α-aryl-β-alkylated ketones via unique 1,2-aryl migration. The procedure is highlighted by its operational simplicity and mild reaction conditions.

Indole synthesis: palladium-catalyzed C-H bond amination via reduction of nitroalkenes with carbon monoxide

Nitroalkenes have been called 'chemical chameleons' due to their versatility in numerous synthetic transformations. Herein, we describe the first transition metal-catalyzed transformation of conjugated nitroalkenes into indoles. Under mild reaction condit

Dications of fluorenylidenes. The relationship between redox potentials and antiaromaticity for meta- and para-substituted diphenylmethylidenefluorenes

Electrochemical oxidation of meta-substituted diphenylmethylidenefluorenes (3a-g) results in the formation of fluorenylidene dications that are shown to be antiaromatic through calculation of the nucleus independent chemical shift (NICS) for the 5- and 6-

Diphenylethylene compounds and uses thereof

The present invention relates to Diphenylethylene Compounds and compositions comprising a Diphenylethylene Compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof one or more Diphenylethylene Compounds. In particular, the invention relates to methods for preventing or treating cancer or an inflammatory disorder by administering to a subject in need thereof one or more Diphenylethylene Compounds. The present invention further relates to articles of manufacture and kits comprising one or more Diphenylethylene Compounds.

A Novel Optically Active Host: Design, Computer Graphics, Synthesis, and Diastereomeric Complex Formation in Aqueous Solution

The application of molecular mechanism (MM2) to the design of the novel optically active macrocyclic host (+)-10 is described.The cavity binding site of host (+)-10 is shaped by both a diphenylmethane and a 4-phenyl-1,2,3,4-tetrahydroisoquinoline unit bri