553664-34-9

Upstream product

• 553664-31-6 1,2-O-isopropyliden-3-O-(2-methoxyethyl)-6-O-(4-phenylbenzoyl)-α-D-allofuranose 
• 553664-30-5 1,2-O-isopropyliden-3-O-(2-methoxyethyl)-α-D-allofuranose 
• 7288-28-0 2,4-bis(trimethylsiloxy)-5-methylpyrimidine 
• 553664-33-8 1,3-di-O-acetyl-2-O-(2-methoxyethyl)-5-O-(4-phenylbenzoyl)-β-D-ribose 
• 553664-29-2 1,2:5,6-di-O-isopropyliden-3-O-(2-methoxyethyl)-α-D-allofuranose 
• 582-52-5 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 
• 2595-05-3 Diacetone D-glucose 

Downstream Products

• 163759-49-7 2'-O-(2-methoxyethyl)-5-methyluridine 

Relevant academic research and scientific papers

A new access to 2′-O-(2-methoxyethyl)ribonucleosides starting from D-glucose

A new synthesis of 2′-O-(2-methoxyethyl)ribonucleosides, building blocks for second-generation antisense oligonucleotides, starting from D-glucose is presented. The key-step is the transformation of 3-O-methoxyethylallofuranose to 2-O-(2-methoxyethyl)ribose by NaIO4 oxidation. Together with the 4′-phenylbenzoyl protecting group, which results in crystalline intermediates, this synthesis provides an easy and cheap access to 2′-O-(2-methoxyethyl)-substituted ribonucleosides.