553664-31-6

Basic information

• Product Name: 1,2-O-isopropyliden-3-O-(2-methoxyethyl)-6-O-(4-phenylbenzoyl)-α-D-allofuranose
• Synonyms: 1,2-O-isopropyliden-3-O-(2-methoxyethyl)-6-O-(4-phenylbenzoyl)-α-D-allofuranose
• CAS NO: 553664-31-6
• Molecular Weight: 458.508
• Mol File: 553664-31-6.mol

Chemical Properties

• CAS DataBase Reference: 1,2-O-isopropyliden-3-O-(2-methoxyethyl)-6-O-(4-phenylbenzoyl)-α-D-allofuranose(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-O-isopropyliden-3-O-(2-methoxyethyl)-6-O-(4-phenylbenzoyl)-α-D-allofuranose(553664-31-6)
• EPA Substance Registry System: 1,2-O-isopropyliden-3-O-(2-methoxyethyl)-6-O-(4-phenylbenzoyl)-α-D-allofuranose(553664-31-6)

Safety Data

• Hazardous Substances Data: 553664-31-6(Hazardous Substances Data)

Upstream product

• 582-52-5 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 
• 553664-29-2 1,2:5,6-di-O-isopropyliden-3-O-(2-methoxyethyl)-α-D-allofuranose 
• 2595-05-3 Diacetone D-glucose 
• 14002-51-8 4-biphenyl-carboxylic acid chloride 
• 553664-30-5 1,2-O-isopropyliden-3-O-(2-methoxyethyl)-α-D-allofuranose 

Downstream Products

• 553664-34-9 3'-O-Acetyl-2'-O-(2-methoxyethyl)-5-methyl-5'-O-(4-phenylbenzoyl)uridin 
• 553664-33-8 1,3-di-O-acetyl-2-O-(2-methoxyethyl)-5-O-(4-phenylbenzoyl)-β-D-ribose 
• 163759-49-7 2'-O-(2-methoxyethyl)-5-methyluridine 

Relevant articles and documents

A new access to 2′-O-(2-methoxyethyl)ribonucleosides starting from D-glucose

A new synthesis of 2′-O-(2-methoxyethyl)ribonucleosides, building blocks for second-generation antisense oligonucleotides, starting from D-glucose is presented. The key-step is the transformation of 3-O-methoxyethylallofuranose to 2-O-(2-methoxyethyl)ribose by NaIO4 oxidation. Together with the 4′-phenylbenzoyl protecting group, which results in crystalline intermediates, this synthesis provides an easy and cheap access to 2′-O-(2-methoxyethyl)-substituted ribonucleosides.