5538-10-3

Basic information

• Product Name: 2-hydroxy-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide
• Synonyms: 2-Hydroxy-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide; Benzamide, 2-hydroxy-N-(5-methyl-1,3,4-thiadiazol-2-yl)-
• CAS NO: 5538-10-3
• Molecular Formula: C₂₂H₂₆O₄
• Molecular Weight: 235.2624
• Mol File: 5538-10-3.mol
• Article Data: 2

Chemical Properties

• Density: 1.48g/cm³
• Refractive Index: 1.709
• CAS DataBase Reference: 2-hydroxy-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide(5538-10-3)
• EPA Substance Registry System: 2-hydroxy-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide(5538-10-3)

Safety Data

• Hazardous Substances Data: 5538-10-3(Hazardous Substances Data)

Upstream product

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Relevant articles and documents

Friedel-Crafts ipso-Acylations of 2-Substituted 4-tert-Butylanisoles and p-tert-Butylmethoxymetacyclophanes

Acylation of 1,n-bis(5-tert-butyl-2-methoxyphenyl)alkanes 6 with acid chloride or acid anhydride in the presence of Lewis acids afforded only the product arizing from two-fold ipso-acylation at the tert-butyl groups; similar reaction of 1,2-bis(5-tert-butyl-2-methoxy-3-methylphenyl)alkanes 8 led only to the recovery of the starting compounds, thus differing from the nitration of 8 with fuming HNO3 at room temperature which affords in quantitative yield the selective ipso-nitration product at the tert-butyl groups.However, the ipso-acylation reactions of 5,13-di-tert-butyl-8,16-dimethoxymeta-cyclophane 15 led to the first-reported direct introduction of an acyl group due to a through-space electronic interaction with the opposing benzene ring.In contrast the selective ipso-acylation reaction was not observed in the case of the larger ring sized macrocyclic meta-cyclophane, p-tert-butyltetramethoxycalix(4)arene.