5538-10-3

Upstream product

• 109560-78-3 (+/-)-12-Methoxy-13-methyl-podocarpatrien-(8,11,13) 
• 94865-59-5 2,4,4-Trimethyl-3-<4-methoxy-3-methyl-phenaethyl>-cyclohexanon-(1) 
• 97830-11-0 2.4.4-Trimethyl-3-(4-methoxy-3-methyl-styryl)-cyclohexen-⁽²⁾-on-⁽¹⁾ 
• 94112-45-5 4-Methyl-1-<4-methoxy-3-methyl-phenyl>-penten-(1)-on-(3) 
• 32723-67-4 3-methyl-4-anisaldehyde 
• 578-58-5 2-methylmethoxybenzene 
• 31040-84-3 4-tert-butyl-2-methylanisole 
• 111-50-2 Adipic acid dichloride 
• 50766-74-0 C₂₈H₃₈O₂S₄ 

Relevant academic research and scientific papers

Friedel-Crafts ipso-Acylations of 2-Substituted 4-tert-Butylanisoles and p-tert-Butylmethoxymetacyclophanes

Acylation of 1,n-bis(5-tert-butyl-2-methoxyphenyl)alkanes 6 with acid chloride or acid anhydride in the presence of Lewis acids afforded only the product arizing from two-fold ipso-acylation at the tert-butyl groups; similar reaction of 1,2-bis(5-tert-butyl-2-methoxy-3-methylphenyl)alkanes 8 led only to the recovery of the starting compounds, thus differing from the nitration of 8 with fuming HNO3 at room temperature which affords in quantitative yield the selective ipso-nitration product at the tert-butyl groups.However, the ipso-acylation reactions of 5,13-di-tert-butyl-8,16-dimethoxymeta-cyclophane 15 led to the first-reported direct introduction of an acyl group due to a through-space electronic interaction with the opposing benzene ring.In contrast the selective ipso-acylation reaction was not observed in the case of the larger ring sized macrocyclic meta-cyclophane, p-tert-butyltetramethoxycalix(4)arene.

Synthesis and structure activity relationships of fibrinolytic 1,ω diphenyl 1,ω alkanediamines

The promising results obtained in animal clot lysis experiments with the fibrinolytic bis(tetrahydroiso quinolines) VI prompted the preparation of a related series of 1,ω diphenyl 1,ω alkanediamines V. As measured in the standard rat screen (ip) the compo