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Usage

Uses

Used in Pharmaceutical Industry:
2-(2-pyridinyl)-1H-Benzimidazol-6-amine is used as a potential pharmaceutical agent for its possible interactions with cellular receptors and its structural properties that may contribute to the development of new drugs. Its specific binding capabilities could be leveraged to target and modulate biological processes, offering therapeutic benefits in treating various diseases.
Used in Antimicrobial Applications:
In the field of antimicrobial research, 2-(2-pyridinyl)-1H-Benzimidazol-6-amine is used as a potential antimicrobial agent. Its chemical structure may allow it to interfere with microbial processes, providing a new avenue for combating resistant strains of bacteria, viruses, or fungi.
Used in Cancer Research:
2-(2-pyridinyl)-1H-Benzimidazol-6-amine is utilized as a candidate for anti-cancer research, where it may exhibit properties that inhibit the growth and proliferation of cancer cells. Its potential to interact with specific biomolecules could lead to the development of targeted therapies for various types of cancer.
Used in Chemical Synthesis:
In the chemical synthesis industry, 2-(2-pyridinyl)-1H-Benzimidazol-6-amine may serve as a building block or intermediate in the synthesis of more complex molecules with specific applications in various fields, including materials science, pharmaceuticals, and agrochemicals.
Further research is essential to fully explore and understand the potential uses and effects of 2-(2-pyridinyl)-1H-Benzimidazol-6-amine across different scientific and medical disciplines. Its unique structural features and properties hold promise for future applications, pending validation through rigorous scientific investigation.

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 1121-60-4 pyridine-2-carbaldehyde 
• 1137-68-4 2-(2'-pyridyl)benzimidazole 
• 98-98-6 2-Picolinic acid 
• 51759-60-5 5-nitro-2-(pyridin-2-yl)-1H-benzo[d]imidazole 

Downstream Products

• 1112986-70-5 phenyl(2-pyridin-2-yl-3H-benzoimidazol-5-y)diazene 

Relevant academic research and scientific papers

Metal-mediated inhibition of escherichia coli methionine aminopeptidase: Structure-activity relationships and development of a novel scoring function for metal-ligand interactions

We report the discovery of thiabendazole as a potent inhibitor (K 1 = 0.4 μM) of Escherichia coli methionine aminopeptidase (ecMetAP) and the synthesis and pharmacological evaluation of thiabendazole congeners with activity in the upper nanomolar range, Elucidation of the X-ray structure of ecMetAP in complex with thiabendazole and an unrelated inhibitor that was independently described by another group showed that that both compounds bind to an additional CoII ion at the entrance of the active site. This unexpected finding explains the inactivity of the compounds under in vivo conditions. It also allows us to discuss the structure-activity relationships of this series of compounds in a meaningful way, based upon docking runs with an auxiliary metal ion, We describe a new scoring function for the evaluation of metal-mediated inhibitor binding that, unlike the previously used scoring function implemented in the docking program, allows us to distinguish between active and inactive compounds, Finally, conclusions for the structure-based design of in vivo-active inhibitors of ecMetAP are drawn.

CARBONYLAMINO-BENZIMIDAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATORS

Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and/or muscle tissue while antagonizing the AR in the prostate of a male patient or

Chemistry of 2-substituted benzimidazoles. 1. 5-Amino-2-methyl(aryl, arylalkyl, pyridyl)benzimidazoles

A series of 2-substituted benzimidazoles was synthesized. These products were consecutively converted into 5-nitro- and 5-amino-2-substituted benzimidazoles.