554-92-7

Usage

Uses

Used in Pharmaceutical Industry:
Trimethobenzamide Hydrochloride is used as an antiemetic agent for the prevention of nausea and vomiting in patients. It is particularly effective in managing these symptoms, which can be caused by various factors such as motion sickness, chemotherapy, or postoperative recovery.
Used in Parkinson's Disease Treatment:
In the treatment of Parkinson's disease, Trimethobenzamide Hydrochloride is used to alleviate some of the symptoms associated with the condition. It helps improve the patient's quality of life by reducing the severity of symptoms such as tremors, rigidity, and bradykinesia.

Therapeutic Function

Antinauseant

InChI:InChI=1/C21H28N2O5.ClH/c1-23(2)10-11-28-17-8-6-15(7-9-17)14-22-21(24)16-12-18(25-3)20(27-5)19(13-16)26-4;/h6-9,12-13H,10-11,14H2,1-5H3,(H,22,24);1H

Upstream product

• 138-56-7 Trimethobenzamide 
• 123-08-0 4-hydroxy-benzaldehyde 
• 15182-92-0 4-(2-dimethylaminoethoxy)benzaldehyde 
• 20059-73-8 4-<2-(dimethylamino)ethoxy>benzylamine 
• 118-41-2 Eudesmic acid 

Relevant academic research and scientific papers

An improved process for trimethobenzamide hydrochloride

An improved process for the preparation of trimethobenzamide hydrochloride conforming to regulatory specification is reported. Specifically, a process for the preparation of trimethobenzamide hydrochloride, which is free from the associated impurities that are normally encountered during coupling of 4-(2-dimethylaminoethoxy)benzyl amine with 3,4,5-trimethoxy benzoic acid is described.

N-(4-Hydroxybenzyl)-3,4,5-trimethoxybenzamide and method for producing trimethobenzamide chlorohydrate

The invention relates to a method for producing trimethobenzamide chlorohydrate. According to such a method, a chloromethilation is carried out on anisle and, after reaction with urotropine followed by acidic hydrolisis, 4-methoxybenzylamide chlorohydrate is obtained which, demethyilated by hydrazoic acid, provides 4-hydroxy benzylamine chlorohydrated that, reacted with 3,4,5-trimethoxybenzoic acid chloride, provides N-(4-Hydroxybenzyl)-3,4,5-trimethoxybenzamide. The latter is per se a novel compound and is also the subject of the invention. This compound is reacted with sodium hydride and N,N-dimethylamino ethyl chloride to provide base trimethobenzamide, the latter being salified with hydrochloric acid.