15182-92-0

Basic information

• Product Name: 4-[2-(DIMETHYLAMINO)ETHOXY]BENZALDEHYDE
• Synonyms: CHEMBRDG-BB 4003884;4-[2-(DIMETHYLAMINO)ETHOXY]BENZALDEHYDE;AKOS BC-2175;TIMTEC-BB SBB010890;p-[2-(dimethylamino)ethoxy]benzaldehyde;4-[2-(Dimethylamino)ethoxy]benzaldehyde 95%;4-[2-(dimethylamino)ethoxy]benzaldehyde(SALTDATA: FREE);Benzaldehyde, 4-[2-(diMethylaMino)ethoxy]-
• CAS NO: 15182-92-0
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.24
• EINECS: 239-234-5
• Mol File: 15182-92-0.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 142 °C
• Flash Point: 141.3 °C
• Appearance: Light yellow powder
• Density: 1.062 g/cm³
• Vapor Pressure: 0.000618mmHg at 25°C
• Refractive Index: 1.542
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Sparingly), DMSO (Sparingly)
• PKA: 8.55±0.28(Predicted)
• CAS DataBase Reference: 4-[2-(DIMETHYLAMINO)ETHOXY]BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(DIMETHYLAMINO)ETHOXY]BENZALDEHYDE(15182-92-0)
• EPA Substance Registry System: 4-[2-(DIMETHYLAMINO)ETHOXY]BENZALDEHYDE(15182-92-0)

Safety Data

• Hazard Codes: C,Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 15182-92-0(Hazardous Substances Data)

Usage

Uses

4-[2-(Dimethylamino)ethoxy]benzaldehyde is used in preparation of cyclosporin A analogs as NTCP inhibitors.

InChI:InChI=1/C11H15NO2/c1-12(2)7-8-14-11-5-3-10(9-13)4-6-11/h3-6,9H,7-8H2,1-2H3

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 107-99-3 2-(dimethylamino)ethyl chloride 
• 44929-30-8 2-(dimethylamino)ethyl methanesulfonate 
• 54373-15-8 4-(2-chloroethoxy)benzaldehyde 
• 124-40-3 dimethyl amine 
• 327077-87-2 2-(4-formylphenoxy)ethyl 4-methylbenzenesulfonate 
• 506-59-2 N,N-dimethylammonium chloride 
• 52191-15-8 4-(2-bromoethyloxy)benzaldehyde 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 6116-74-1 2-(dimethylamino)ethyl methanesulfonate monohydrochloride 

Downstream Products

• 217964-97-1 bis(2,5-dimethyl-4-hydroxyphenyl)[4-(2-dimethylamino-1-ethoxy)phenyl]methane 
• 129791-56-6 2-[p-[(E)-2-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)propenyl]phenoxy]-N,N-dimethylethylamine 
• 1172118-45-4 2-{4-[2-dimethylaminoethoxy]phenyl}-4,5-diphenylimidazole 
• 122898-67-3 itopride 
• 10540-29-1 tamoxifen 
• 13002-65-8 (E)-tamoxifen 
• 748-97-0 1-(4-(2-(dimethylamino)ethoxy)phenyl)-1,2-diphenylbutan-1-ol 
• 60891-07-8 3-[4-[2-(Dimethylamino)ethoxy]phenyl]-2,3,3a,4-tetrahydro-2-methyl-indeno[1,2-c]pyrazole, hydrochloride 

Relevant articles and documents

4-PHENYL-N-(PHENYL)THIAZOL-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS

4-phenyl-N-(phenyl)thiazol-2-amine and 4-(pyridin-3-yl)-N-( phenyl) thiazol-2-amine derivatives and the corresponding thiadiazole, thiophene, oxazole, oxadiazole, imidazole and triazole derivatives and related compounds as aryl hydrocarbon receptor (AHR) agonists for the treatment of angiogenesis implicated disorders, such as e.g. retinopathy, psoriasis, rheumatoid arthritis, obesity and cancer, or inflammatory disorders.

Overcoming inaccessibility of fluorinated imines-synthesis of functionalized amines from readily available fluoroacetamides

Although imines are convenient substrates for the synthesis of functionalized amines, they may be hard to obtain, as in the case of fluorinated imines. To aid in overcoming this issue, we propose a protocol of corresponding amine synthesis from simple fluoroacetic acid-derived amides using Schwartz's reagent.

HETEROARYL INHIBITORS OF PAD4

The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.