55414-45-4

Basic information

• Product Name: (2-amino-3-bromo-5-fluorophenyl)methanol
• Synonyms: (2-amino-3-bromo-5-fluorophenyl)methanol
• CAS NO: 55414-45-4
• Molecular Formula: C₇H₇BrFNO
• Molecular Weight: 220.0389832
• Mol File: 55414-45-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-amino-3-bromo-5-fluorophenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-amino-3-bromo-5-fluorophenyl)methanol(55414-45-4)
• EPA Substance Registry System: (2-amino-3-bromo-5-fluorophenyl)methanol(55414-45-4)

Safety Data

• Hazardous Substances Data: 55414-45-4(Hazardous Substances Data)

Usage

General Description

(2-amino-3-bromo-5-fluorophenyl)methanol is a chemical compound with the molecular formula C7H7BrFNO. It is a phenol derivative that contains an amino group, a bromine atom, and a fluorine atom attached to a phenyl ring. It is commonly used in organic synthesis and medicinal chemistry as a building block for the synthesis of pharmaceuticals and agrochemicals. The compound has potential applications in the development of new drugs and as a precursor to produce various functionalized aromatic compounds. Additionally, it may also have uses as a chemical intermediate in the production of organic and biochemical products. Overall, (2-amino-3-bromo-5-fluorophenyl)methanol possesses useful properties and applications in the field of chemistry and drug discovery.

Upstream product

• 446-08-2 2-amino-5-fluorobenzoic acid 
• 259269-84-6 2-amino-3-bromo-5-fluorobenzoic acid 

Downstream Products

• 953039-61-7 2-amino-3-bromo-5-fluorobenzaldehyde 
• 100-44-7 benzyl chloride 
• 953039-62-8 8-bromo-6-fluoro-quinazolin-2-ol 
• 953039-63-9 8-bromo-2-chloro-6-fluoroquinazoline 

Relevant articles and documents

CONDENSED-RING PYRIMIDYLAMINO DERIVATIVE, PREPARATION METHOD THEREFOR, AND INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND APPLICATIONS THEREOF

Disclosed are a condensed-ring pyrimidylamino derivative, a preparation method therefor, and an intermediate, a pharmaceutical composition and applications thereof. The method for preparing the condensed-ring pyrimidylamino derivative comprises: in a solvent, in the presence of a palladium-containing catalyst, allowing a compound represented by formula I-a and a compound represented by formula I-b' to have a coupling reaction, and then preparing a compound represented by formula I by means of a deprotection reaction. Also disclosed applications of the condensed-ring pyrimidylamino derivative in the preparation of drugs for preventing, relieving and/or treating tumors or diseases caused by an anaplastic lymphoma kinase. The condensed-ring pyrimidylamino derivative of the present invention has an obvious restraint effect on the anaplastic lymphoma kinase.

QUINAZOLINES FOR PDK1 INHIBITION

The invention provides novel quinazoline compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.