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8-Bromo-2-chloro-6-fluoro-quinazoline is a specialized chemical compound that belongs to the class of quinazolines, characterized by a 2-azabicyclo[2.2.2]octane moiety with three nitrogen atoms at the 1-, 3-, and 4positions. It is further distinguished by the presence of a bromine atom at the 8-position, a chlorine atom at the 2-position, and a fluorine atom at the 6-position. 8-BroMo-2-chloro-6-fluoro-quinazoline is not commonly found in nature and is primarily used in laboratory settings for research on new pharmaceuticals and other synthetic compounds. Its unique structure and properties make it a valuable component in chemical reactions of interest in synthetic and medicinal chemistry.

953039-63-9

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953039-63-9 Usage

Uses

Used in Pharmaceutical Research:
8-Bromo-2-chloro-6-fluoro-quinazoline is used as a key intermediate in the synthesis of various pharmaceutical compounds for [application reason]. Its unique structure and properties allow for the development of new drugs with potential therapeutic benefits.
Used in Synthetic Chemistry:
In the field of synthetic chemistry, 8-Bromo-2-chloro-6-fluoro-quinazoline is used as a building block for the creation of complex organic molecules. Its specific halogens and nitrogen atoms enable it to participate in a variety of chemical reactions, facilitating the synthesis of novel compounds with potential applications in various industries.
Used in Medicinal Chemistry:
8-Bromo-2-chloro-6-fluoro-quinazoline is employed as a starting material in the design and synthesis of new drug candidates. Its unique structural features make it a promising candidate for the development of targeted therapies and other medicinal agents.
Used in Chemical Reactions of Interest:
Due to its specific structure and properties, 8-Bromo-2-chloro-6-fluoro-quinazoline is used in chemical reactions of considerable interest in both synthetic and medicinal chemistry. Its participation in these reactions can lead to the formation of new compounds with potential applications in various fields.

Check Digit Verification of cas no

The CAS Registry Mumber 953039-63-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,3,0,3 and 9 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 953039-63:
(8*9)+(7*5)+(6*3)+(5*0)+(4*3)+(3*9)+(2*6)+(1*3)=179
179 % 10 = 9
So 953039-63-9 is a valid CAS Registry Number.

953039-63-9 Well-known Company Product Price

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  • Alfa Aesar

  • (H66128)  8-Bromo-2-chloro-6-fluoroquinazoline, 95%   

  • 953039-63-9

  • 250mg

  • 1680.0CNY

  • Detail
  • Alfa Aesar

  • (H66128)  8-Bromo-2-chloro-6-fluoroquinazoline, 95%   

  • 953039-63-9

  • 1g

  • 5040.0CNY

  • Detail

953039-63-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 8-Bromo-2-chloro-6-fluoroquinazoline

1.2 Other means of identification

Product number -
Other names QC-509

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:953039-63-9 SDS

953039-63-9Downstream Products

953039-63-9Relevant articles and documents

METHODS OF CULTURING AND/OR EXPANDING STEM CELLS AND/OR LINEAGE COMMITTED PROGENITOR CELLS USING AMIDO COMPOUNDS

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Paragraph 0361; 0582, (2020/02/14)

Provided are methods for expanding stem cells and/or lineage committed progenitor cells, such as hematopoietic stems cells and/or lineage committed progenitor cells, at least in part, by using compounds that antagonize AhR. The compounds are represented by formulae (I) (II) (III) (IV), wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.

AMIDO COMPOUNDS AS AhR MODULATORS

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Paragraph 0230; 0451, (2019/02/06)

Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae Formula (I), (II), (III), (iv): wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification.

CONDENSED-RING PYRIMIDYLAMINO DERIVATIVE, PREPARATION METHOD THEREFOR, AND INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND APPLICATIONS THEREOF

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, (2018/03/25)

Disclosed are a condensed-ring pyrimidylamino derivative, a preparation method therefor, and an intermediate, a pharmaceutical composition and applications thereof. The method for preparing the condensed-ring pyrimidylamino derivative comprises: in a solvent, in the presence of a palladium-containing catalyst, allowing a compound represented by formula I-a and a compound represented by formula I-b' to have a coupling reaction, and then preparing a compound represented by formula I by means of a deprotection reaction. Also disclosed applications of the condensed-ring pyrimidylamino derivative in the preparation of drugs for preventing, relieving and/or treating tumors or diseases caused by an anaplastic lymphoma kinase. The condensed-ring pyrimidylamino derivative of the present invention has an obvious restraint effect on the anaplastic lymphoma kinase.

FUSED RING PYRIMIDINE COMPOUND, INTERMEDIATE, AND PREPARATION METHOD, COMPOSITION AND USE THEREOF

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, (2018/08/12)

Disclosed area fused ring pyrimidine compound, and an intermediate, a preparation method, a composition and a use thereof. The fused ring pyrimidine compound is a compound as shown in formula I, a tautomer, an enantiomer, a diastereoisomer, a pharmaceutically acceptable salt, a metabolite, a metabolic precursor or a prodrug thereof, wherein the above-mentioned compound is used for the preparation of a medicine for preventing, remitting or treating one or more of immune system diseases, autoimmune diseases, cell proliferative diseases, allergic disorders and cardiovascular diseases, and the compound has a strong inhibitory effect on the Janues kinase, FGFR kinase, FLT3 kinase and Src family kinase.

Substituted piperazine compounds, application method and applications thereof

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Paragraph 0206; 0207; 0208; 0209; 0239; 0240; 0241; 0242, (2016/10/09)

The invention discloses substituted piperazine compounds, an application method and applications thereof. Specifically, the invention relates to piperazine compounds and pharmaceutical compositions thereof for inhibiting reuptake of 5-hydroxytryptamine and/or stimulation of 5-HT1A acceptor. The invention also relates to a preparation method of the compounds and pharmaceutical compositions thereof, and an application of the compounds and pharmaceutical compositions thereof in the treatment of central nervous system dysfunction.

QUINAZOLINES FOR PDK1 INHIBITION

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, (2008/06/13)

The invention provides novel quinazoline compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.

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