554418-71-2Relevant academic research and scientific papers
Rh-catalyzed aerobic oxidative cyclization of anilines, alkynes, and CO
Li, Xinyao,Pan, Jun,Wu, Hao,Jiao, Ning
, p. 6266 - 6273 (2017)
Transition-metal-catalyzed oxidative C-H cyclization of anilines has been an attractive and powerful strategy for the efficient construction of N-heterocycles. However, primary and tertiary anilines are rarely employed in this strategy due to the relative instability with strong oxidants or the presence of three C-N bonds. We describe here a novel Rh-catalyzed C-H cyclization of a wide range of anilines with alkynes and CO, using an aerobic oxidative protocol. Particularly, the simple primary anilines and readily prepared tertiary anilines could be easily converted to quinolin-2(1H)-ones, which are high value-added, biologically significant N-heterocycles, via C-N bond cleavage.
NOVEL PHENYLALANINE DERIVATIVE
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Page 52; 56, (2010/02/08)
Phenylalanine derivatives of the following formula, analogues thereof and pharmaceutically acceptable salts thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents or preventive agents for various diseases concerning α4 i
