554429-87-7

Upstream product

• 554430-98-7 5-[4-(2-(piperidin-1-yl)ethoxy)phenyl]-5,11-dihydrochromeno[4,3-c]-chromene-2,8-diol 
• 3282-30-2 pivaloyl chloride 
• 554430-39-6 2,8-bis(tert-butyldimethylsilyloxy)-5-[4-(2-(piperidin-1-yl)ethoxy)phenyl]-5,11-dihydrochromeno[4,3-c]chromene 
• 554430-69-2 2,8-dihydroxy-11H-chromeno[4,3-c]chromen-5-one 
• 554430-12-5 2-(4-(hydroxy-(4-(2-(piperidin-1-yl)ethoxy)phenyl)methyl))-7-(tert-butyldimethylsilyloxy-2H-chromen-3-yl)-5-(tertbutyldimethylsilyloxy)phenol 
• 553681-47-3 2,8-bis(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]chromen-5-ol 
• 554430-87-4 2,8-bis(tert-butyl-dimethyl-silyloxy)-11H-chromeno[4,3-c]chromen-5-one 

Downstream Products

• 554429-89-9 (5S)-2,2-dimethylpropionic acid 8-(2,2-dimethylpropionyloxy)-5-[4-(2-(piperidin-1-yl)ethoxy)phenyl]-5,11-dihydrochromeno[4,3-c]-chromene-2-yl ester 
• 554429-88-8 2,2-dimethyl-propionic acid 8-(2,2-dimethyl-propionyloxy)-5(R)-[4-(2-piperidin-1-yl-ethoxy)phenyl]-5,11-dihydro-chromeno[4,3-c]chromen-2-yl ester 

Relevant academic research and scientific papers

Synthesis of tetracyclic heterocompounds as selective estrogen receptor modulators. Part 1. Process development for scale-up of 2,5,8-substituted 5,11 -dihydrochromeno[4,3-c]chromene derivatives

Unsymmetrical benzopyranobenzopyran compounds are novel selective estrogen receptor modulators (SERMs). A reproducible and nonchromatographic process was developed to prepare multihundred gram quantities of 5-(4-(2-(piperidin-1-yl) ethoxy)-phenyl)-5,11-di

Novel chromene-derived selective estrogen receptor modulators useful for alleviating hot flushes and vaginal dryness

A novel SERM (selective estrogen receptor modulators), 1-(R), a chromene-derived bisbenzopyran, was discovered to alleviate hot flushes and effectively increase vaginal fluidity in rats. Moreover, 1-(R) was found to have beneficial effects on plasma chole

Novel heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators

The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders mediated by one or more estrogen receptors and processes for their preparation. The compounds of the invention are useful in the treatment and/or prevention of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.