554429-89-9

Upstream product

• 554430-98-7 5-[4-(2-(piperidin-1-yl)ethoxy)phenyl]-5,11-dihydrochromeno[4,3-c]-chromene-2,8-diol 
• 554430-39-6 2,8-bis(tert-butyldimethylsilyloxy)-5-[4-(2-(piperidin-1-yl)ethoxy)phenyl]-5,11-dihydrochromeno[4,3-c]chromene 
• 554430-12-5 2-(4-(hydroxy-(4-(2-(piperidin-1-yl)ethoxy)phenyl)methyl))-7-(tert-butyldimethylsilyloxy-2H-chromen-3-yl)-5-(tertbutyldimethylsilyloxy)phenol 
• 554430-69-2 2,8-dihydroxy-11H-chromeno[4,3-c]chromen-5-one 
• 3282-30-2 pivaloyl chloride 
• 553681-47-3 2,8-bis(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]chromen-5-ol 
• 554430-87-4 2,8-bis(tert-butyl-dimethyl-silyloxy)-11H-chromeno[4,3-c]chromen-5-one 
• 554429-87-7 2,2-dimethyl-propionic acid 8-(2,2-dimethyl-propionyloxy)-5-[4-(2-piperidin-1-yl-ethoxy)phenyl]-5,11-dihydro-chromeno[4,3-c]chromen-2-yl ester 

Relevant academic research and scientific papers

Synthesis of tetracyclic heterocompounds as selective estrogen receptor modulators. Part 1. Process development for scale-up of 2,5,8-substituted 5,11 -dihydrochromeno[4,3-c]chromene derivatives

Unsymmetrical benzopyranobenzopyran compounds are novel selective estrogen receptor modulators (SERMs). A reproducible and nonchromatographic process was developed to prepare multihundred gram quantities of 5-(4-(2-(piperidin-1-yl) ethoxy)-phenyl)-5,11-di

Novel chromene-derived selective estrogen receptor modulators useful for alleviating hot flushes and vaginal dryness

A novel SERM (selective estrogen receptor modulators), 1-(R), a chromene-derived bisbenzopyran, was discovered to alleviate hot flushes and effectively increase vaginal fluidity in rats. Moreover, 1-(R) was found to have beneficial effects on plasma chole