554429-98-0

Upstream product

• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 6496-89-5 2,4-dimethoxyphenylacetic acid 
• 108-24-7 acetic anhydride 
• 6496-88-4 4-[(2,4-dimethoxy-phenyl)-thioacetyl]-morpholine 
• 829-20-9 2',4'-dimethoxyacetophenone 

Downstream Products

• 553681-50-8 4-methyl-3-(2,4-dihydroxyphenyl)-7-hydroxycoumarin 
• 554430-78-3 3-(2,4-dimethoxy-phenyl)-7-methoxy-4-methyl-chromen-2-one 
• 749901-81-3 4-bromomethyl-3-[(2,4-dimethoxy)phenyl]-7-methoxycoumarin 
• 554430-37-4 3-[2,4-bis(2-trimethylsilylethoxymethoxy)phenyl]-4-bromomethyl-7-(2-trimethylsilylethoxymethoxy)coumarin 
• 554430-09-0 7-acetoxy-4-bromomethyl-3-[(2,4-diacetoxy)phenyl]-coumarin 
• 554430-36-3 3-[2,4-bis(2-trimethylsilylethoxymethoxy)phenyl]-4-methyl-7-(2-trimethylsilanylethoxymethoxy)coumarin 
• 554430-18-1 5-(tert-butyl-dimethyl-silyloxy)-2-[7-(tert-butyl-dimethyl-silyloxy)-4-(hydroxy-phenyl-methyl)-2H-chromen-3-yl]-phenol 
• 554430-95-4 2,8-bis-(tert-butyl-dimethyl-silyloxy)-5-phenyl-5,11-dihydro-chromeno[4,3-c]-chromene 

Relevant academic research and scientific papers

FUSED TETRACYCLIC HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES

The present invention relates to novel Fused Tetracyclic Heterocyclic Compounds of Formula I: (I), wherein A, A', R2A, R2B, R7, R8, R9, and R10 are defined herein. The compounds and their p

FUSED TETRACYCLIC HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES

The present invention relates to novel Fused Tetracyclic Heterocyclic Compounds of Formula (I): wherein A, A', R2A, R2B, R7, R8, R9 and R10 are defined herein. The compounds and their pharm

Synthesis of tetracyclic heterocompounds as selective estrogen receptor modulators. Part 1. Process development for scale-up of 2,5,8-substituted 5,11 -dihydrochromeno[4,3-c]chromene derivatives

Unsymmetrical benzopyranobenzopyran compounds are novel selective estrogen receptor modulators (SERMs). A reproducible and nonchromatographic process was developed to prepare multihundred gram quantities of 5-(4-(2-(piperidin-1-yl) ethoxy)-phenyl)-5,11-di

Development of a scalable synthetic process for selective bromination of 4-methyl-3,7-substituted coumarins

The hydroxyl-protected coumarin derivatives 6a-e of 4-methyl-3-(2,4- dihydroxyphenyl)-7-hydroxycoumarin (4) are key intermediates in the synthesis of unsymmetrical benzopyranobenzopyran compounds, a novel series of selective estrogen receptor modulators (

A facile synthesis of an unsymmetric benzopyranobenzopyran ring system

A facile route to the synthesis of an unsymmetric benzopyranobenzopyran ring system is described. A key feature of this synthesis incorporates a tandem deprotection-cyclization strategy to construct the C-ring of the tetracyclic system.

Novel heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators

The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders mediated by one or more estrogen receptors and processes for their preparation. The compounds of the invention are useful in the treatment and/or prevention of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.