749901-81-3

Upstream product

• 554429-98-0 7-acetoxy-3-(2,4-dimethoxyphenyl)-4-methylcoumarin 
• 6496-89-5 2,4-dimethoxyphenylacetic acid 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 6496-88-4 4-[(2,4-dimethoxy-phenyl)-thioacetyl]-morpholine 
• 829-20-9 2',4'-dimethoxyacetophenone 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 554430-78-3 3-(2,4-dimethoxy-phenyl)-7-methoxy-4-methyl-chromen-2-one 

Downstream Products

• 554430-38-5 C₁₆H₁₁BrO₅ 
• 554430-95-4 2,8-bis-(tert-butyl-dimethyl-silyloxy)-5-phenyl-5,11-dihydro-chromeno[4,3-c]-chromene 
• 554430-18-1 5-(tert-butyl-dimethyl-silyloxy)-2-[7-(tert-butyl-dimethyl-silyloxy)-4-(hydroxy-phenyl-methyl)-2H-chromen-3-yl]-phenol 

Relevant academic research and scientific papers

FUSED TETRACYCLIC HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES

The present invention relates to novel Fused Tetracyclic Heterocyclic Compounds of Formula (I): wherein A, A', R2A, R2B, R7, R8, R9 and R10 are defined herein. The compounds and their pharm

FUSED TETRACYCLIC HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES

The present invention relates to novel Fused Tetracyclic Heterocyclic Compounds of Formula I: (I), wherein A, A', R2A, R2B, R7, R8, R9, and R10 are defined herein. The compounds and their p

Synthesis of tetracyclic heterocompounds as selective estrogen receptor modulators. Part 1. Process development for scale-up of 2,5,8-substituted 5,11 -dihydrochromeno[4,3-c]chromene derivatives

Unsymmetrical benzopyranobenzopyran compounds are novel selective estrogen receptor modulators (SERMs). A reproducible and nonchromatographic process was developed to prepare multihundred gram quantities of 5-(4-(2-(piperidin-1-yl) ethoxy)-phenyl)-5,11-di

Development of a scalable synthetic process for selective bromination of 4-methyl-3,7-substituted coumarins

The hydroxyl-protected coumarin derivatives 6a-e of 4-methyl-3-(2,4- dihydroxyphenyl)-7-hydroxycoumarin (4) are key intermediates in the synthesis of unsymmetrical benzopyranobenzopyran compounds, a novel series of selective estrogen receptor modulators (

Synthesis of novel tetracyclic chromenes through carbanion chemistry of 4-methyl coumarins

Various substituents were introduced onto the methyl group in 4-methyl coumarins through lithiation, followed by reactions with a wide range of electrophiles. The presence of an alkoxy group on 6′-phenyl ring was found to be pivotal for the success of thi

A facile synthesis of an unsymmetric benzopyranobenzopyran ring system

A facile route to the synthesis of an unsymmetric benzopyranobenzopyran ring system is described. A key feature of this synthesis incorporates a tandem deprotection-cyclization strategy to construct the C-ring of the tetracyclic system.