554430-18-1Relevant articles and documents
FUSED TETRACYCLIC HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
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, (2015/07/07)
The present invention relates to novel Fused Tetracyclic Heterocyclic Compounds of Formula (I): wherein A, A', R2A, R2B, R7, R8, R9 and R10 are defined herein. The compounds and their pharm
FUSED TETRACYCLIC HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
-
, (2015/07/07)
The present invention relates to novel Fused Tetracyclic Heterocyclic Compounds of Formula I: (I), wherein A, A', R2A, R2B, R7, R8, R9, and R10 are defined herein. The compounds and their p
Novel chromene-derived selective estrogen receptor modulators useful for alleviating hot flushes and vaginal dryness
Jain, Nareshkumar,Kanojia, Ramesh M.,Xu, Jiayi,Jian-Zhong, Guo,Pacia, Emmanuel,Lai, Muh-Tsann,Du, Fuyong,Musto, Amy,Allan, George,Hahn, DoWon,Lundeen, Scott,Sui, Zhihua
, p. 3056 - 3059 (2007/10/03)
A novel SERM (selective estrogen receptor modulators), 1-(R), a chromene-derived bisbenzopyran, was discovered to alleviate hot flushes and effectively increase vaginal fluidity in rats. Moreover, 1-(R) was found to have beneficial effects on plasma chole
Novel heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators
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Page/Page column 46, (2010/01/31)
The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders mediated by one or more estrogen receptors and processes for their preparation. The compounds of the invention are useful in the treatment and/or prevention of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.