554446-27-4Relevant academic research and scientific papers
2,5-Diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 3. Synthesis, pharmacokinetics, and in vivo potency
Borthwick, Alan D.,Davies, Dave E.,Exall, Anne M.,Hatley, Richard J. D.,Hughes, Jennifer A.,Irving, Wendy R.,Livermore, David G.,Sollis, Steve L.,Nerozzi, Fabrizio,Valko, Klara L.,Allen, Michael J.,Perren, Marion,Shabbir, Shalia S.,Woollard, Patrick M.,Price, Mark A.
, p. 4159 - 4170 (2007/10/03)
A short, efficient, and highly stereoselective synthesis of a series of (3R,6R,7R)-2,5-diketopiperazine oxytocin antagonists and their pharmacokinetics in rat and dog is described. Prediction of the estimated human oral absorption (EHOA) using measured li
