554451-61-5Relevant academic research and scientific papers
Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)
Duan, James J.-W.,Chen, Lihua,Lu, Zhonghui,Jiang, Bin,Asakawa, Naoyuki,Sheppeck II, James E.,Liu, Rui-Qin,Covington, Maryanne B.,Pitts, William,Kim, Soong-Hoon,Decicco, Carl P.
, p. 266 - 271 (2007/10/03)
Using a pyrimidine-2,4,6-trione motif as a zinc-binding group, a series of selective inhibitors of tumor necrosis factor-α converting enzyme (TACE) was discovered. Optimization of initial lead 1 resulted in a potent inhibitor (51), with an IC50
Barbituric acid derivatives as inhibitors of TNF-alpha converting enzyme (TACE) and/or matrix metalloproteinases
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Page/Page column 39, (2008/06/13)
The present application describes novel barbituric acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, R2, R3, R4, R5, n, W, U, X, Y, Z, U
