554451-61-5Relevant articles and documents
Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)
Duan, James J.-W.,Chen, Lihua,Lu, Zhonghui,Jiang, Bin,Asakawa, Naoyuki,Sheppeck II, James E.,Liu, Rui-Qin,Covington, Maryanne B.,Pitts, William,Kim, Soong-Hoon,Decicco, Carl P.
, p. 266 - 271 (2007/10/03)
Using a pyrimidine-2,4,6-trione motif as a zinc-binding group, a series of selective inhibitors of tumor necrosis factor-α converting enzyme (TACE) was discovered. Optimization of initial lead 1 resulted in a potent inhibitor (51), with an IC50