554451-62-6

Upstream product

• 554451-61-5 4-(2-methyl-quinolin-4-ylmethoxy)-N-pyridin-4-ylmethyl-benzamide 
• 99-96-7 4-hydroxy-benzoic acid 
• 63825-02-5 N-(4-pyridylmethyl)-4-hydroxybenzamide 
• 3731-53-1 4-(aminomethyl)pyridine 

Downstream Products

• 554451-59-1 4-[(2-methyl-4-quinolinyl)methoxy]-N-[(5-methyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-(4-pyridinyl)methyl]benzamide trifluoroacetate 

Relevant academic research and scientific papers

Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)

Using a pyrimidine-2,4,6-trione motif as a zinc-binding group, a series of selective inhibitors of tumor necrosis factor-α converting enzyme (TACE) was discovered. Optimization of initial lead 1 resulted in a potent inhibitor (51), with an IC50

Barbituric acid derivatives as inhibitors of TNF-alpha converting enzyme (TACE) and/or matrix metalloproteinases

The present application describes novel barbituric acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, R2, R3, R4, R5, n, W, U, X, Y, Z, U