1528-42-3

Usage

Uses

Used in Perfumery and Fragrance Industry:
Ethyl 4-acetylphenylacetate is used as a fragrance ingredient for its floral and fruity scent, enhancing the aroma profiles of various perfumes and scented products.
Used in Food Industry:
Ethyl 4-acetylphenylacetate is used as a flavoring agent, providing a sweet and fruity taste to a range of food products, enhancing their flavor profiles and consumer appeal.
Used in Organic Solvent Applications:
Due to its solubility in organic solvents and insolubility in water, ethyl 4-acetylphenylacetate is used in various applications where organic solvents are required, such as in the formulation of certain types of cleaning products or industrial processes.
Ethyl 4-acetylphenylacetate is considered safe for use in consumer products and does not pose significant health risks when used as directed, making it a preferred choice for various applications in different industries.

InChI:InChI=1/C12H14O3/c1-3-15-12(14)8-10-4-6-11(7-5-10)9(2)13/h4-7H,3,8H2,1-2H3

Upstream product

• 101-97-3 Ethyl 2-phenylethanoate 
• 75-36-5 acetyl chloride 
• 681-94-7 ethyl 2-(tributylstannyl)acetate 
• 99-90-1 para-bromoacetophenone 
• 75-15-0 carbon disulfide 
• 7446-70-0 aluminium trichloride 
• 105-36-2 ethyl bromoacetate 
• 171364-81-1 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone 
• 149104-90-5 4-acetylphenylboronic acid 
• 99-91-2 para-chloroacetophenone 
• 105-53-3 diethyl malonate 
• 75-34-3 1,1-dichloroethane 
• 64-17-5 ethanol 
• 201230-82-2 carbon monoxide 

Downstream Products

• 55453-49-1 ethyl 4-(ω-bromoacetyl)phenylacetate 
• 176643-46-2 2-(4-acetyl-phenyl)-3-(2,2-dimethyl-[1,3]dioxolan-4-yl)-propionic acid ethyl ester 
• 81950-33-6 (4-Benzo[d]imidazo[2,1-b]thiazol-2-yl-phenyl)-acetic acid 
• 81950-37-0 (4-Benzo[d]imidazo[2,1-b]thiazol-2-yl-phenyl)-acetic acid ethyl ester 
• 81950-35-8 [4-(7-Fluoro-benzo[d]imidazo[2,1-b]thiazol-2-yl)-phenyl]-acetic acid 
• 81950-34-7 [4-(7-Chloro-benzo[d]imidazo[2,1-b]thiazol-2-yl)-phenyl]-acetic acid 
• 81950-46-1 [4-(7-Methoxy-benzo[d]imidazo[2,1-b]thiazol-2-yl)-phenyl]-acetic acid 
• 81950-45-0 [4-(7-Fluoro-benzo[d]imidazo[2,1-b]thiazol-2-yl)-phenyl]-acetic acid ethyl ester 
• 81950-38-1 [4-(7-Chloro-benzo[d]imidazo[2,1-b]thiazol-2-yl)-phenyl]-acetic acid ethyl ester 
• 81950-36-9 [4-(7-Ethoxy-benzo[d]imidazo[2,1-b]thiazol-2-yl)-phenyl]-acetic acid 
• 81950-39-2 [4-(7-Methoxy-benzo[d]imidazo[2,1-b]thiazol-2-yl)-phenyl]-acetic acid ethyl ester 
• 81950-40-5 [4-(7-Ethoxy-benzo[d]imidazo[2,1-b]thiazol-2-yl)-phenyl]-acetic acid ethyl ester 
• 52787-14-1 methyl 4-(2-methoxy-2-oxoethyl)benzoate 
• 22744-12-3 [4-(methoxycarbonyl)phenyl]acetic acid 

Relevant academic research and scientific papers

Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters

We have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale.

Non-natural amino acid and application thereof Recombinant protein and recombinant protein conjugate comprising same

The invention provides a non-natural amino acid. A compound represented by formula (I) or an enantiomer thereof. The invention also provides application of the non-natural amino acid. Further, the present invention also provides a protein conjugate comprising the recombinant protein and of the non-natural amino acid prepared from the recombinant protein. The non-natural amino acid provided by the invention is simple and convenient to prepare, good in safety, not prone to inactivation during protein insertion, high in conjugate rate with a coupling part, and higher in stability of the obtained conjugate.

Desulfurative Ni-Catalyzed Reductive Cross-Coupling of Benzyl Mercaptans/Mercaptoacetates with Aryl Halides

The C-S activation and sulfur removal from native thiols is challenging, which limits their application as feedstock materials in organic synthesis despite their natural abundance. Herein, we introduce a per-/polyfluoroaryl moiety, which serves as a redox-active scaffold, into sp3-hybridized thiols to activate the C-S bond. Using a Ni catalyst with MgBr2 as an additive, the S group can be removed to yield an aliphatic radical that can react with an aryl halide in a reductive cross-coupling.

Catalytic C-C coupling of diazo compounds with arylboronic acids: Using surface modified sewage sludge as catalyst

A green, mild and efficient synthesis of diarylmethines using sewage sludge-derived carbonaceous materials (SW) by perchloric acid catalyzed coupling reactions between diazo compounds and arylboronic acids was developed. The reaction shows a high level of functional tolerance and a broad substrate scope. Furthermore, the highly selective 1,2-alkyl shift products were furnished through the sterically demanding R4, R5 migration of diazo compounds (3-diazochromanone). The structures of 1,2-shift products have been further confirmed by single-crystal X-ray analysis. Significantly, the synthesis of the core structures of darifenacin (a clinical drug for overactive bladder syndrome, OAB) and diclofensine (a stimulant drug showing antidepressant and monoamine reuptake inhibitor activity) further demonstrated the efficacy and synthetic potential of this method. This journal is

PERIODONTAL DISEASE THERAPY

Disclosed are formulations for oral films and other compositions containing therapeutic agents. The therapeutic agents interfere with succinate/succinate receptor signaling. The films and compositions of the present disclosure can be used to treat periodontal disease.

OXIDATIVE COUPLING OF ARYL BORON REAGENTS WITH SP3-CARBON NUCLEOPHILES, AND AMBIENT DECARBOXYLATIVE ARYLATION OF MALONATE HALF-ESTERS VIA OXIDATIVE CATALYSIS

Described herein are methods of oxidative coupling of aryl boron reagents with sp3-carbon nucleophiles, and ambient decarboxylative arylation of malonate half-esters via oxidative catalysis.

Isoflavone amide type derivative, preparation method and medical application thereof

The invention relates to the field of medicinal chemistry, and relates to an isoflavone amide type derivative, a preparation method and a medical application thereof, in particular to an isoflavone amide type derivative with the general formula (I), a preparation method thereof, medicine compositions including the isoflavone amide type derivative and a medical application thereof, especially an application of the isoflavone amide type derivative as a medicine for preventing or curing hyperlipemia, obesity or type II diabetes. The general formula (I) is shown in the description.

Ambient Decarboxylative Arylation of Malonate Half-Esters via Oxidative Catalysis

We report decarboxylative carbonyl α-arylation by coupling of arylboron nucleophiles with malonic acid derivatives. This process is enabled by the merger of aerobic oxidative Cu catalysis with decarboxylative enolate interception reminiscent of malonyl-CoA reactivity in polyketide biosynthesis. This method enables the synthesis of monoaryl acetate derivatives containing electrophilic functional groups that are incompatible with existing α-arylation reactivity paradigms. The utility of the reaction is demonstrated in drug intermediate synthesis and late-stage functionalization.

PROCESS FOR PREPARING ARYL- AND HETEROARYLACETIC ACID DERIVATIVES

The invention relates to a process for preparing aryl- and heteroarylacetic acids and derivatives thereof by reaction of aryl or heteroaryl halides with malonic diesters in the presence of a palladium catalyst, of one or more bases and optionally of a phase transfer catalyst. This process enables the preparation of a multitude of functionalized aryl- and heteroarylacetic acids and derivatives thereof, especially also the preparation of arylacetic acids with sterically demanding substituents.

Alcohol assisted C-C bond breaking: Copper-catalyzed deacetylative α-arylation of β-keto esters and amides

A method of alcohol-assisted copper-catalyzed highly selective deacetylative α-arylation of β-keto esters and amides has been demonstrated, which illustrated an efficient example of achieving α-aryl esters and amides. From the synthetic point of view, this arylation protocol is general and practical, representing a simple way to produce α-arylated carbonyl compounds from basic starting materials at low cost.