1528-42-3

Basic information

• Product Name: ethyl 4-acetylphenylacetate
• Synonyms: (4-Acetylphenyl)acetic acid ethyl ester;4-Acetylbenzeneacetic acid ethyl ester;Benzeneacetic acid,4-acetyl-, ethyl ester;ethyl 4-acetylphenylacetate
• CAS NO: 1528-42-3
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 206.23776
• EINECS: 216-206-0
• Mol File: 1528-42-3.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 315.5°Cat760mmHg
• Flash Point: 137.4°C
• Appearance: /
• Density: 1.083g/cm³
• Vapor Pressure: 0.000435mmHg at 25°C
• Refractive Index: 1.509
• CAS DataBase Reference: ethyl 4-acetylphenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-acetylphenylacetate(1528-42-3)
• EPA Substance Registry System: ethyl 4-acetylphenylacetate(1528-42-3)

Safety Data

• Hazardous Substances Data: 1528-42-3(Hazardous Substances Data)

Usage

General Description

Ethyl 4-acetylphenylacetate is a chemical compound with the molecular formula C12H14O3. It is a combination of ethyl, acetyl, and phenylacetate functional groups, and is commonly used in the production of perfumes and other fragrance products due to its pleasant floral and fruity scent. ethyl 4-acetylphenylacetate is also used as a flavoring agent in the food industry, providing a sweet and fruity taste to various products. Ethyl 4-acetylphenylacetate is insoluble in water but soluble in organic solvents, making it suitable for use in a wide range of applications. Additionally, it is considered safe for use in consumer products and does not pose significant health risks when used as directed.

InChI:InChI=1/C12H14O3/c1-3-15-12(14)8-10-4-6-11(7-5-10)9(2)13/h4-7H,3,8H2,1-2H3

Upstream product

• 75-34-3 1,1-dichloroethane 
• 101-97-3 Ethyl 2-phenylethanoate 
• 75-36-5 acetyl chloride 
• 13329-40-3 4-Iodoacetophenone 
• 623-73-4 diazoacetic acid ethyl ester 
• 149104-90-5 4-acetylphenylboronic acid 
• 1071-46-1 hydrogen ethyl malonate 
• 460088-33-9 1-(4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)ethan-1-one 
• 141-97-9 ethyl acetoacetate 
• 64-17-5 ethanol 
• 201230-82-2 carbon monoxide 
• 122-00-9 para-methylacetophenone 
• 99-90-1 para-bromoacetophenone 
• 105-53-3 diethyl malonate 

Downstream Products

• 7398-52-9 4-acetyl-phenylacetic acid 
• 7325-46-4 1,4-phenylenediacetic acid 
• 81950-33-6 (4-Benzo[d]imidazo[2,1-b]thiazol-2-yl-phenyl)-acetic acid 
• 81950-37-0 (4-Benzo[d]imidazo[2,1-b]thiazol-2-yl-phenyl)-acetic acid ethyl ester 
• 81950-35-8 [4-(7-Fluoro-benzo[d]imidazo[2,1-b]thiazol-2-yl)-phenyl]-acetic acid 
• 81950-34-7 [4-(7-Chloro-benzo[d]imidazo[2,1-b]thiazol-2-yl)-phenyl]-acetic acid 
• 81950-46-1 [4-(7-Methoxy-benzo[d]imidazo[2,1-b]thiazol-2-yl)-phenyl]-acetic acid 
• 81950-45-0 [4-(7-Fluoro-benzo[d]imidazo[2,1-b]thiazol-2-yl)-phenyl]-acetic acid ethyl ester 
• 81950-38-1 [4-(7-Chloro-benzo[d]imidazo[2,1-b]thiazol-2-yl)-phenyl]-acetic acid ethyl ester 
• 81950-36-9 [4-(7-Ethoxy-benzo[d]imidazo[2,1-b]thiazol-2-yl)-phenyl]-acetic acid 
• 81950-39-2 [4-(7-Methoxy-benzo[d]imidazo[2,1-b]thiazol-2-yl)-phenyl]-acetic acid ethyl ester 
• 81950-40-5 [4-(7-Ethoxy-benzo[d]imidazo[2,1-b]thiazol-2-yl)-phenyl]-acetic acid ethyl ester 
• 1314796-00-3 N-[(S)-1-(4'-fluoro-3'-trifluoromethylbiphenyl-4-yl)ethyl]-2-[4-([1,8]naphthyridin-2-yl)phenyl]acetamide 
• 1324054-53-6 methyl 4-(2-(2,4-dihydroxyphenyl)-2-oxoethyl)benzoate 

Relevant articles and documents

Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters

We have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale.

Desulfurative Ni-Catalyzed Reductive Cross-Coupling of Benzyl Mercaptans/Mercaptoacetates with Aryl Halides

The C-S activation and sulfur removal from native thiols is challenging, which limits their application as feedstock materials in organic synthesis despite their natural abundance. Herein, we introduce a per-/polyfluoroaryl moiety, which serves as a redox-active scaffold, into sp3-hybridized thiols to activate the C-S bond. Using a Ni catalyst with MgBr2 as an additive, the S group can be removed to yield an aliphatic radical that can react with an aryl halide in a reductive cross-coupling.

PERIODONTAL DISEASE THERAPY

Disclosed are formulations for oral films and other compositions containing therapeutic agents. The therapeutic agents interfere with succinate/succinate receptor signaling. The films and compositions of the present disclosure can be used to treat periodontal disease.