55456-74-1Relevant academic research and scientific papers
Iron(III)-Catalyzed Peroxide-Mediated C-3 Functionalization of Flavones
Mir, Bilal Ahmad,Banerjee, Arghya,Santra, Sourav Kumar,Rajamanickam, Suresh,Patel, Bhisma K.
, p. 3471 - 3476 (2016/11/13)
An iron(III)-catalyzed C-3 functionalization of flavones has been achieved using tert-butyl peroxybenzoate (TBPB)/potassium persulphate (K2S2O8) oxidant combinations with a suitable solvent. In the presence of iron(III)/tert-butyl peroxybenzoate/potassium persulphate, the reaction of flavones in cycloalkanes afforded exclusive C-3 cycloalkylation via Csp2–Csp3coupling, whereas the solvent N,N-dialkylformamide provided C-3 amidation via Csp2–Csp3coupling. Under identical reaction conditions just by switching the solvent to chlorobenzene, C-3 methylated flavones were obtained where tert-butyl peroxybenzoate (TBPB) served as the source of the methyl group. (Figure presented.).
One-pot synthesis of 3-methylflavones and their transformation into (E)-3-styrylflavones via Wittig reactions
Rocha, Djenisa H. A.,Pinto, Diana C. G. A.,Silva, Artur M. S.
, p. 2683 - 2686 (2014/01/06)
An efficient one-pot synthesis of 3-methylflavone derivatives is established. Furthermore, their transformation into phosphorus ylides, which are then used in the diastereoselective synthesis of (E)-styrylflavones through Wittig reactions, is also studied
Synthesis of 3-methylflavones and their antioxidant and antibacterial activities
Jayashree, B. S.,Alam, Afroze,Vijay Kumar, D.,Nayak, Yogendra
, p. 1991 - 1996,6 (2020/07/30)
An attempt was made to synthesise newer 3-methylflavones with various substitution on the ring A and B of 2-phenylchromen-4-one. They were evaluated for antioxidant activity and antibacterial activity against the Gram-positive and Gram-negative bacteria.
Antioxidant and antibacterial activity of new 3-methylflavones
Jayashree,Alam, Afroze,Kumar, D. Vijay,Nayak, Yogendra
, p. 237 - 240 (2011/12/15)
Synthesis of new 3-methylflavones with various substitution on the ring A and B is being described. They were evaluated for antioxidant and antibacterial activity against Gram positive and Gram negative bacteria. Test compounds such as F-4,9,11,12 and 20
Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme
Gobbi, Silvia,Cavalli, Andrea,Rampa, Angela,Belluti, Federica,Piazzi, Lorna,Paluszcak, Anja,Hartmann, Rolf W.,Recanatini, Maurizio,Bisi, Alessandra
, p. 4777 - 4780 (2007/10/03)
Following our SAR studies on aromatase inhibitors, new compounds were designed by appropriately modifying the structure of flavone 1 using our previously reported CoMFA model. While the introduction of substituents on the 2-phenyl ring alone did not cause
