55476-04-5

Upstream product

• 6289-19-6 O-α,α-dimethylpropargyl N-phenylcarbamate 
• 57492-34-9 4-(Z)-bromomethylene-5,5-dimethyl-3-phenyl-oxazolidin-2-one 
• 29199-96-0 4-hydroxy-4,5,5-trimethyl-3-phenyl-oxazolidin-2-one 
• 4437-80-3 4,4-dimethyl-5-methylene-1,3-dioxolan-2-one 
• 62-53-3 aniline 
• 124-38-9 carbon dioxide 
• 115-19-5 2-methyl-but-3-yn-2-ol 
• 77-75-8 meparfynol 
• 59255-63-9 3-methyl-3-phenylcarbamoyloxy-butan-2-one 
• 3422-02-4 N-(benzyloxycarbonyl)aniline 
• 115-22-0 3-Hydroxy-3-methyl-2-butanone 
• 2063-19-6 4-bromo-2-methylbut-3-yn-2-ol 
• 103-71-9 phenyl isocyanate 
• 102-07-8 bis(diphenyl)urea 

Downstream Products

• 57492-44-1 4-(E)-bromomethylene-5,5-dimethyl-3-phenyl-oxazolidin-2-one 
• 24201-26-1 5,5-dimethyl-3-phenyl-2,4-oxazolidinedione 
• 59255-88-8 4,5,5-trimethyl-3-phenyl-oxazolidin-2-one 
• 29199-96-0 4-hydroxy-4,5,5-trimethyl-3-phenyl-oxazolidin-2-one 
• 99833-61-1 C₁₉H₁₅N₃O₇ 
• 99833-56-4 C₁₉H₁₅Br₂NO₃ 
• 99833-52-0 C₂₃H₁₉NO₃ 
• 99833-51-9 C₂₃H₁₉NO₃ 
• 99833-62-2 C₁₉H₁₅ClN₂O₅ 
• 99833-63-3 C₁₉H₁₅BrN₂O₅ 
• 99833-50-8 C₂₀H₁₉NO₃ 
• 99833-60-0 C₁₉H₁₆N₂O₅ 
• 99833-49-5 2-oxo-3-phenyl-5,5-dimethylspiro(1,3-oxazolidine-4,2'-<2H>-chromene) 
• 99833-57-5 C₂₀H₁₉NO₄ 

Relevant academic research and scientific papers

Comparison between Conventional and Nonconventional Methods for the Synthesis of Some 2-Oxazolidinone Derivatives and Preliminary Investigation of Their Inhibitory Activity Against Certain Protein Kinases

A series of propargyl and allyl carbamates were prepared directly from propargyl and allyl alcohols and phenyl or cyclohexyl isocyanate or indirectly by generating the isocyanates in situ from the corresponding Cbz-protected amines. The obtained carbamate

Effective guanidine-catalyzed synthesis of carbonate and carbamate derivatives from propargyl alcohols in supercritical carbon dioxide

The reactions of propargyl alcohols with carbon dioxide in supercritical carbon dioxide or in acetonitrile with gaseous carbon dioxide in the presence of organic bases as catalysts have been examined. Bicyclic guanidines are effective catalysts for the formation of α-methylene cyclic carbonates under mild reaction conditions. Oxoalkyl carbonates, oxoalkyl carbamates or α-methyleneoxazolidinones are obtained in high yields and good selectivities in one-step starting from propargyl alcohols and an external nucleophile (alcohols or amines) using bicyclic guanidines as catalysts in supercritical carbon dioxide. Propargylic diols under the same reaction conditions underwent a rearrangement process instead of carbon dioxide insertion whereas in the presence of an external nucleophile the formation of oxocarbonates, oxocarbamates or cyclic carbamates was achieved in satisfactory yields.

Versatile synthesis of quaternary 1,3-oxazolidine-2,4-diones and their use in the preparation of α-hydroxyamides

A new approach to the synthesis of 1,3-oxazolidine-2,4-diones, via a two-step reaction sequence, starting from the readily available α-ketols and isocyanates, is reported. The condensation of the latter led to the key precursors 4-methylene-2-oxazolidinon

A single-step synthesis of 4-oxazolin-2-ones and their use in the construction of polycyclic structures bearing quaternary stereocenters

A new method for the synthesis of 4-oxazolin-2-ones by a one-pot MW-promoted condensation of a-ketols and isocyanates is reported. An alternative thermal approach using the same starting materials is also described. These cyclic enamides were efficient nucleophiles, reacting with Michael acceptors and prenyl bromide to give a variety of polycyclic structures bearing one or two quaternary stereocenters. The selectivity of the products depended on the reaction conditions and on the electrophile used. Wiley-VCH Verlag GmbH & Co. KGaA.

Regioselective 1,3-dipolar cycloaddition reactions of 4-methylene-2- oxazolidinones with benzonitrile oxide

Substituted 4-methylene-2-oxazolidinones were prepared in two steps by cyclizing O-propargyl carbamates, which in turn were prepared from propargyl alcohols and phenyl isocyanate. The 4-methylene-2-oxazolidinones underwent a 1,3-dipolar cycloaddition reac

Reactions of 5-methylene-1,3-dioxolan-2-ones with amines. Synthesis of 2-oxazolidinones

The reaction of 5-methylene-1,3-dioxolan-2-ones with aromatic or aliphatic amines as well as with the sodium salts of amino acids leads to 4-hydroxy-2-oxazolidinones. The reaction conditions depend on the basicity of the amines. The use of o-phenylenediamine in this reaction leads to the formation of a new heterocyclic system. 1999 KluwerAcademic/Plenum.

A simple synthesis of oxazolidinones in one step from carbon dioxide

The reaction of carbon dioxide, propargyl alcohol derivatives and primary amines, catalysed by phosphine, gives N-substituted 4-methylene-oxazolidin-2-ones.

Selectivity of Anionic Activation by Fluoride Ion in Solid-Liquid Systems. Synthesis of Tetramic Acids and 4-Methylene-1,3-oxazolidin-2-ones.

The butanamides 1, treated with cesium fluoride in the presence of benzyltriethylammonium chloride, give the tetramic acids 3.In the same way, the fluoride ion-induced reaction of N,N'-diarylureas with 3-hydroxy-3-methylbutan-2-one gives 3-aryl-4-methylene-1,3-oxazolidin-2-ones.