18781-58-3

Usage

Uses

Used in Pharmaceutical Industry:
2,3,3-Trimethyl-2,3-dihydro-1H-indole is used as a potential therapeutic agent for the treatment of mental health conditions such as depression, anxiety, and neurodegenerative diseases. Its psychoactive properties and traditional use in medicine suggest that it may have beneficial effects on these conditions, warranting further research and development.
Used in Psychopharmacology Research:
In the field of psychopharmacology, 2,3,3-Trimethyl-2,3-dihydro-1H-indole is used as a subject of ongoing research to explore its potential role in drug development. Its psychoactive properties and presence in traditional medicine make it a promising candidate for the creation of new treatments for various mental health disorders.
Used in Traditional Medicine:
2,3,3-Trimethyl-2,3-dihydro-1H-indole has been used in traditional medicine for its psychoactive properties, often in the context of religious rituals and cultural practices. Its historical use provides a foundation for modern research into its potential therapeutic applications.

Upstream product

• 1640-39-7 2,3,3-trimethylindoleniune 
• 118-12-7 1,3,3-Trimethyl-2-methyleneindoline 
• 10034-85-2 hydrogen iodide 
• 617-86-7 triethylsilane 
• 563-80-4 3-methyl-butan-2-one 
• 59-88-1 phenylhydrazine hydrochloride 
• 7647-01-0 hydrogenchloride 
• 13034-76-9 1,2,3,3-tetramethylindoline 
• 615-36-1 2-bromoaniline 
• 55476-04-5 4,4-Dimethyl-5-methylen-2-oxo-1-phenyl-1,3-oxazolidin 

Downstream Products

• 1640-39-7 2,3,3-trimethylindoleniune 
• 126535-40-8 2,3,3-Trimethyl-2,3-dihydro-indole-1-carbonyl chloride 
• 88920-01-8 2,3,3-trimethyl-1-phenacylindoline 
• 1612872-77-1 N-(1-acetyl-2,3,3-trimethylindolin-7-yl)-4-methylbenzenesulfonamide 
• 62783-91-9 C-(1,3,3-trimethyl-2-methylene-2,3-dihydro-indol-5-yl)-methylamine 

Relevant academic research and scientific papers

Cu-Catalyzed Chemoselective Reduction of N-Heteroaromatics with NH3·BH3 in Aqueous Solution

An efficient catalytic system was successfully developed on reduction of N-heteroaromatics with H3N?BH3 as hydrogen source in CuSO4 solution, featuring excellent chemoselectivity as well as very broad functional group tolerance. Various challenging substrates, such as OH-, NH2-, Cl-, Br-, etc., contained quinolines, quinoxalines, 1,5-naphthyridines and quinazolines were all reduced smoothly. Mechanistic studies suggested that [Cu-H] intermediate might be generated from NH3?BH3, which was believed to form with H3N?BH3 in CuSO4 solution.

Novel squarylium compounds, resin composition for absorbing near infrared ray including the same and absorbing near infrared ray blocking filter manufactured by using this

The present invention refers to near infrared filter a squarylium compound, including near-infrared absorbing resin composition for same, a near-infrared cut filter and their use relates to search using the number bath, more specifically maximum absorption wavelength is 630 - 750 nm, light absorption coefficient and good solubility in the near-infrared cut filter mole for near-infrared absorbing processed a squarylium compound, near-infrared absorbing resin composition and by using a near-infrared cut filter to number tank are disclosed. (by machine translation)

METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND, AND NOVEL METAL-DIAMINE COMPLEX

The present invention pertains to a method for producing an optically active compound which includes a step for reducing an imino group of an imine compound or a step for reducing an unsaturated bond of a heterocyclic compound, while in the presence of hydrogen gas as a hydrogen donor and one or more types of complexes selected from a group consisting of a complex represented by general formula (1), a complex represented by general formula (2), a complex represented by general formula (3), and a complex represented by general formula (4) (the general formulas (1)-(4) are as stipulated by claim 1).

SQUARYLIUM DYES

Squarylium dyes with improved design flexibility via functionalization thereof thereby yielding desirable photophysical, solubility, thermal stability, and/or light stability properties, for example. The resulting dyes are useful in optical filters and as fluorescent indicators, for example.

Oxidative palladium(II)-catalyzed dehydrogenative C-H/C-H cross-coupling of 2,3-substituted indolines with arenes at the C7 position

Directed directing group: The C7 position of the indoline nucleus is difficult to address in C-H activation. An oxidative palladium(II) catalysis that allows for cross-dehydrogenative coupling in that position with activation of the C-H bond of the arene component is disclosed here. This C-H/C-H cross-coupling is applicable to various indolines acetylated at the nitrogen atom. Substitution at C2 is crucial for the C-H activation to occur at C7 (see scheme).

A supramolecular approach to chiral ligand modification: Coordination chemistry of a multifunctionalised tridentate amine-phosphine ligand

A novel chiral amine-phosphine tagged with an amido-napthyridine moiety has been synthesised and found to bind complementary pyridinone additives. These additives were found to have a modest but measurable promotional effect on the catalytic activity and/or enantioselectivity of Ir- and Rh-catalysed reductions. One explanation for the relatively poor results obtained with the Ir and Ru catalysts is the formation of complexes, in which the ligand adopts an anionic tridentate coordination mode. Pt and Rh complexes of this type were isolated and characterised. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.

Catalytic behavior of cationic hydridoruthenium(II) complex, [RuH(NH 3)(PMe3)4]+, in H 2-hydrogenation and transfer hydrogenation of imines

Catalytic hydrogenation under H2 and transfer hydrogenation of imines by secondary alcohols with hydridoruthenium complexes bearing PMe 3 and PPh3 ligands have been examined. A cationic hydridoruthenium complex, cis-[RuH-(NH3)(PMe3) 4]PF6 (2), derived from cis-[RuH2(PMe 3)4] (1) and NH4PF6, showed higher catalytic activity for H2-hydrogenation of N-benzylideneaniline than neutral complexes such as 1 and cis- [RuClH(PMe3)4] (6). The effectiveness of cationic hydridoruthenium species for the catalytic H 2-hydrogenation of benzylideneaniline was also demonstrated by a marked increase in the yield of N-benzylaniline on treatment of 6 with AgPF 6. The cationic complex 2 was applicable to catalytic transfer hydrogenation of imines with secondary alcohols even in the absence of a base. Isotope labeling experiments using deuterated alcohols revealed that the hydrogen atom bound to the α-carbon of the donor alcohol was transferred exclusively to the imine carbon and alcoholic OD was transferred to the imine nitrogen. A rapid exchange between the alcoholic proton and the hydrido ligand of 2 was also confirmed by NMR investigation using (CH3) 2CHOD. On the basis of the experimental results the mechanisms of the H2-hydrogenation and transfer hydrogenation are discussed.

Imine hydrogenation catalyzed by iridium complexes comprising monodentate chiral phosphoramidites and N-donor ligands

The relatively inexpensive chiral monodentate phosphoramidite (S)-MONOPHOS may be used in combination with pyridines to prepare iridium complexes effective for catalysis of asymmetric imine hydrogenation with comparable enantioselectivity to some of those containing more costly chiral bidentate phosphines. [Ir(cod)((S)-MONOPHOS)(L)]BArF (cod = 1,5-cyclooctadiene; L = 3-methylisoquinoline, acridine, 2,6-lutidine, acetonitrile, or 2,3,3-trimethylindolenine; BArF = tetrakis[3,5-bis(trifluoromethyl)phenyl]borate) are efficient catalysts for the asymmetric hydrogenation of 2,3,3-trimethylindolenine. An important observation is that the catalyst containing acridine is more enantioselective than the catalyst derived from 2,3,3-trimethylindolenine which suggests that the other N-donor ligands are not readily displaced by the substrate during the catalytic cycle.

Iridium(I)-catalysed tandem hydrosilylation-protodesilylation of imines

In the presence of alkylsilanes, the cationic IrI complex [{Ir[bis(pyrazol-1-yl)methane](CO)2}BPh4] (1) catalyses the reduction of a range of imines, including N-alkyl and N-aryl imines, and both aldimines and ketimines. Excellent conversions directly to the product amines are achieved rapidly at room temperature in methanol solution. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.

Photoreduction of imines. An environmentally friendly approach to obtain amines

The photoreduction of different imines to amines in alcoholic solvents is reported. The reduction involves a versatile and chemoselective methodology that is environmentally friendly in that it avoids the use of metal hydrides and other dangerous reducing agents.