55478-53-0Relevant articles and documents
Calycosin derivative as well as preparation method and application thereof
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Paragraph 0028; 0029' 0030, (2017/01/02)
The invention relates to a calycosin derivative as well as a preparation method and application thereof, belonging to the field of medicinal chemistry. The calycosin derivative is of a structure A shown in the specification, wherein R1 and R2 are out one
Haem d1: Development of a new coupling procedure leading to the synthesis of isobacteriochlorins
Mackman, Richard L.,Micklefield, Jason,Block, Michael H.,Leeper, Finian J.,Battersby, Alan R.
, p. 2111 - 2122 (2007/10/03)
A new approach has been developed for construction of the western and eastern lactams, e.g. 2 and 3, needed for synthesis of isobacteriochlorins. It involves acylation of pyrroles with lactonic acids to form ketones. These are then efficiently converted into the desired lactams by a short sequence of reactions. All the steps are high yielding and simple to carry out.