5626-52-8

Usage

Uses

Used in Pharmaceutical Industry:
5-OXOPYRROLIDINE-2-CARBOXAMIDE is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs and medications.
Used in Agrochemical Industry:
5-OXOPYRROLIDINE-2-CARBOXAMIDE is used as an intermediate in the synthesis of agrochemicals, playing a role in the creation of products that support agricultural processes and pest control.
Used in Polymer and Resin Production:
5-OXOPYRROLIDINE-2-CARBOXAMIDE is used as a component in the production of polymers and resins, where its stability and compatibility enhance the properties of these materials for various applications.

InChI:InChI=1/C5H8N2O2/c6-5(9)3-1-2-4(8)7-3/h3H,1-2H2,(H2,6,9)(H,7,8)

Upstream product

• 56-86-0 L-glutamic acid 
• 16450-41-2 L-glutamic acid diethyl ester 
• 55478-53-0 pyroglutamoyl chloride 
• 149-87-1 Pyroglutamic acid 
• 4931-66-2 methyl 5-oxopyrrolidine-2-carboxylate 
• 4344-84-7 5-oxo-tetrahydro-furan-2-carboxylic acid 
• 7664-41-7 ammonia 

Downstream Products

• 617-65-2 Glutamic acid 
• 6893-26-1 D-Glutamic acid 
• 5626-50-6 5-cyano-2-pyrrolidinone 
• 98062-39-6 N-chloroacetylpyroglutamic acid nitrile 
• 106203-75-2 N-phenylacetylpyroglutamic acid nitrile 
• 92503-18-9 ethyl 4,5-diamino-5-oxopentanoate hydrochloride 

Relevant academic research and scientific papers

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.

Impact of Functional Groups on the Copper-Initiated N-Arylation of 5-Functionalized Pyrrolidin-2-ones and Their Vinylogues

The electronic effects governing the N-arylation of pyrrolidone were investigated. The generalization of our preliminary findings on a copper(I)-catalyzed Csp2-N coupling process was first improved with a wide variety of aryl and heteroaryl halides and methyl pyroglutamate. The optimized protocol was further extended to pyrrolidin-2-ones substituted at the C5-position with an aryl group bearing an electron-donating or electron-withdrawing group as well as to some of their substituted enaminoester vinylogues. The impact of substituents at the N- and C5-position on these coupling processes seemed to be pivotal for determining both the reaction profiles and yields.

Chemie der α-Aminonitrile. 1. Mitteilung. Einleitung und Wege zu Uroporphyrinogen-octanitrilen

Chemistry of α-Aminonitriles I: Introduction and Pathways to Uroporphyrinogen-octanitriles.An introduction to experimental studies on the chemistry of α-aminonitriles potentially relevant to the problems of prebiotic chemistry is presented.The framework of conditions wherein the investigations is chosen to be carried out implies both molecular oxygen and - whenever feasible - water to be excluded from reaction conditions.This study focusses on 2-amino-2-propenenitrile (3) (Scheme 6) as central starting material of reaction sequences which aim at the nitrile forms of proteinogenic amino acids as well as at the aza forms of building blocks of biological cofactor molecules as their targets (Scheme 5).Schemes 13, 16, 23 as well as 25, and 26 summarize reaction sequences by which 3 is tranformed within the definied framework of conditions into the thermodynamic (statistically controlled) mixture of the four isomeric uroporphyrinogen-octanitriles 57-60.HPLC's of such mixtures document the dominance of the least symmetrical isomer whose constitutional pattern of peripheral substituents happens to be the one present in all biological porphinoids.Preparative procedures for the synthesis of 3 (Scheme 9), the β,β-disubstututed pyrrol-nitriles 30, 53, and 54 (Scheme 19) as well as the porphyrinogen-octakis(propionitrile) and -octakis(acetonitrile) 65 and 66, respectively (Scheme 24) are given.

Method for making aminoacid amides

The present process describes a new and improved method for making the amides of an aminoacid. The new procedure involves only two steps, produces good yield and requires neither isolation nor purification of the intermediate. It also assures that the optical rotation of the starting material is not affected.