55482-60-5Relevant academic research and scientific papers
178. Stereoselectivity of the Radical Reductive Alkylation of Enamines: Importance of the Allylic 1,3-Strain Model
Schubert, Serge,Renaud, Philippe,Carrupt, Pierre-Alain,Schenk, Kurt
, p. 2473 - 2489 (1993)
Radical addition to enamines using Bu3SnH as reducing agent are reported (Schemes 2 and 4).The diastereoselectivity of these reactions was examined in different systems (Tables 1 and 2).Enamines derived from cyclic ketones such as cyclohexanone were alkyl
Highly diastereo- and enantioselective copper-catalyzed propargylic alkylation of acyclic ketone enamines for the construction of two vicinal stereocenters
Zhang, De-Yang,Zhu, Fu-Lin,Wang, Ya-Hui,Hu, Xin-Hu,Chen, Song,Hou, Chuan-Jin,Hu, Xiang-Ping
supporting information, p. 14459 - 14462 (2015/02/19)
The first highly diastereo- and enantioselective propargylic alkylation of acyclic ketone enamines to form vicinal tertiary stereocenters has been reported by employing copper catalysis in combination with a bulky and structurally rigid tridentate ketimine P,N,N-ligand.
