55505-26-5

Upstream product

• 64-17-5 ethanol 
• 54247-27-7 1-bromo-6-benzyloxyhexane 

Downstream Products

• 67953-27-9 oleic acid-(8-methyl-nonyl ester) 
• 55504-89-7 (8-Methyl-nonyloxysulfonyl)-phenyl-acetic acid 
• 136539-94-1 (8-Methyl-nonyl)-triphenyl-phosphonium; bromide 
• 951221-77-5 8-methylnonyl 3-(4-hydroxy-3-methoxyphenyl)propionate 
• 951221-76-4 8-methylnonyl homovanillate 
• 62950-20-3 dibutyl cyclohexane-1,2-dicarboxylate 
• 890090-93-4 isodecyl benzoate 
• 89-16-7 diisodecyl phthalate 
• 677354-23-3 (Z)-11-methyldodec-2-enoic acid 
• 1346599-15-2 isodecyl diphenyl phosphate 
• 838-85-7 diphenyl hydrogen phosphate 
• 108-95-2 phenol 

Relevant academic research and scientific papers

Validating the 1,2-Difluoro Motif As a Hybrid Bioisostere of CF3and et Using Matrix Metalloproteinases As Structural Probes

Matrix metalloproteinases (MMPs) are involved in a spectrum of physiological processes, rendering them attractive targets for small-molecule drug discovery. Strategies to achieve selective inhibition continue to be intensively pursued, facilitated by advances in structural biology. Herein, we harness MMPs 2, 8, 9, and 13 to validate the vicinal difluoro motif as a hybrid bioisostere of CF3 and Et (BITE) in a series of modified barbiturate inhibitors. Crystallographic analyses of representative structures reveal conformations of the vicinal difluoro motif that manifest stabilizing hyperconjugative interactions consistent with the stereoelectronic gauche effect. Detailed docking studies of a potent difluorinated probe with MMP-9 are also disclosed and indicate that the structural basis of inhibition is a consequence of the anisotropic nature of the motif. Significant selectivity of MMP 13 versus MMP-2 can be achieved by subtle chain contraction in a BITE-modified inhibitor.

METHOD OF SYNTHESIZING HIGHER-MOLECULAR ALCOHOL

A clean process for efficiently producing, from ethanol as a raw material, higher-molecular alcohols having an even number of carbon atoms, such as 1-butanol, hexanol, octanol, and decanol and a mixture of these. The higher-molecular alcohols are yielded from ethanol as a starting material with the aid of a calcium phosphate compound, e.g., hydroxyapatite Ca10(PO4)6(OH)2, tricalcium phosphate Ca3(PO4)2, calcium monohydrogen phosphate CaHPO4·(0-2)H2O, calcium diphosphate Ca2P2O7, octacalcium phosphate Ca8H2(PO4)6·5H2O, tetracalcium phosphate Ca4(PO4)2O, or amorphous calcium phosphate Ca3(PO4)2·nH2O, preferably hydroxyapatite, as a catalyst, the contact time being 0.4 seconds or longer.