55507-06-7Relevant academic research and scientific papers
Copper(II/I) complexes of 5-pyridin-2-yl-[1,3]dioxolo[4,5-g]isoquinoline: Synthesis, crystal structure, antitumor activity and DNA interaction
Huang, Ke-Bin,Chen, Zhen-Feng,Liu, Yan-Cheng,Wang, Meng,Wei, Jian-Hua,Xie, Xiao-Li,Zhang, Jian-Lian,Hu, Kun,Liang, Hong
, p. 640 - 648 (2013)
Three new copper(II) complexes of 5-pyridin-2-yl-[1,3]dioxolo[4,5-g] isoquinoline (PYP), i.e. [Cu2(PYP)2Cl4] (1), [Cu4(PYP)4(ClO4)2(H 2O)2](ClO4)
Co(III)-Catalyzed Annulative Vinylene Transfer via C-H Activation: Three-Step Total Synthesis of 8-Oxopseudopalmatine and Oxopalmatine
Li, Xinghua,Huang, Ting,Song, Ying,Qi, Yue,Li, Limin,Li, Yanping,Xiao, Qi,Zhang, Yuanfei
supporting information, p. 5925 - 5930 (2020/08/12)
The Co(III)-catalyzed redox-neutral annulation of benzamides and acrylamides with vinylene carbonate for the synthesis of isoquinolinones and pyridinones has been developed. This protocol employing inexpensive Co(III) as the catalyst tolerated diverse functional groups and substitution patterns, affording the target products with good to excellent yields. The synthetic utility of this transformation was demonstrated by a three-step synthesis of gusanlung D, 8-oxopseudopalmatine, and oxopalmatine.
Direct Amidation of Carboxylic Acids through an Active α-Acyl Enol Ester Intermediate
Xu, Xianjun,Feng, Huangdi,Huang, Liliang,Liu, Xiaohui
, p. 7962 - 7969 (2018/06/18)
The development of a highly efficient and simple protocol for the direct amidation of carboxylic acids is described employing ynoates as novel coupling reagents. The transformation proceeds in good to excellent yields via in situ α-acyl enol ester intermediates formation under mild reaction conditions. This useful method has been demonstrated for a range of substrates to provide a succinct access to structurally diverse amides, including key intermediates of glibenclamide, tiapride hydrochloride, and nateglinide, and can be conducted on a mole scale.
Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives as potential antitumor candidate
Zhu, Panhu,Ye, Wenfeng,Li, Jiaming,Zhang, Yanchun,Huang, Weijun,Cheng, Mohan,Wang, Yujun,Zhang, Yang,Liu, Huicai,Zuo, Jian
, p. 443 - 455 (2017/04/03)
A novel class of tetrahydroisoquinoline derivatives was designed and synthesized as antitumor agents and evaluated for their in vitro and in vivo biological activities. The antiproliferative activities of all the target compounds on HUVEC, MCF-7, and HT-2
Pd(II)-Catalyzed Intramolecular Tandem Olefin Amidation/C-H Activation Protocol for the Syntheses of the Protoberberine Class of Natural Products
Garad, Dnyaneshwar N.,Mhaske, Santosh B.
supporting information, p. 3862 - 3865 (2016/08/16)
A Pd(II)-catalyzed intramolecular tandem olefin amidation/C-H activation protocol has been developed for the synthesis of an 8-oxoprotoberberine core. It was successfully applied for the syntheses of (±)-8-oxocanadine, (±)-8-oxotetrahydropalmitine, and (±
