55515-10-1

Upstream product

• 133906-63-5 (+/-)-2-Hydroxymethyl-6,7-methylenedioxy-4-(3',4',5'-trimethoxyphenyl)-1,2-dihydro-3-naphthoic acid 
• 6642-34-8 6-bromopiperonyl alcohol 
• 15930-53-7 6-bromo-3,4-methylenedioxybenzaldehyde 
• 82792-81-2 1-(3,4,5-trimethoxyphenyl)-5,6-methylenedioxy-1,3-dihydrobenzothiophene-2,2-dioxide 
• 82792-83-4 -3,4-methylenedioxybenzyl alcohol 
• 82792-85-6 5,6-methylenedioxy-1-(3,4,5-trimethoxyphenyl)-1,3-dihydrobenzothiophene 
• 120-57-0 piperonal 
• 128014-53-9 (+)-γ-apopodophyllic acid 
• 82792-91-4 6,7-methylenedioxy-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydro-2,3-naphthoic anhydride 
• 6258-32-8 (dl)-5-(3,4,5-trimethoxyphenyl)-8a,9-dihydrofuro[3′,4’:6,7]-naphtho[2,3-d][1,3]dioxol-6(8H)-one 

Downstream Products

• 55515-11-2 isodeoxypodophyllinic acid methyl ester 
• 477-51-0 (5S,5aS,8aR)-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3′,4’:6,7]naphtho[2,3-d][1,3]-dioxol-6(5aH)-one 
• 477-51-0 (+/-)-Isopicrodesoxypodophyllotoxin 
• 83023-41-0 (+)-Isodeoxypicropodophyllin 
• 477-51-0 deoxypodophyllotoxin 

Relevant academic research and scientific papers

Efficient Asymmetric Syntheses of Naturally Occurring Lignan Lactones Using Catalytic Asymmetric Hydrogenation as a Key Reaction

Optically pure (R)-arylmethylsuccinic acid mono-methyl esters were obtained efficiently by using the catalytic asymmetric hydrogenation of arylidenesuccinic acid monoesters with a rhodium(I) complex of a chiral bisphosphine, (4S,5S)-MOD-DIOP.Asymmetric total syntheses of some naturally occurring lignans, (+)-collinusin, (-)-deoxypodophyllotoxin, and (+)-neoisostegane, were achieved via several steps from (R)-γ-butyrolactones as key intermediates obtained by reduction of (R)-arylmethylsuccinic acid mono methyl-esters.

The Synthesis of Lignans and Related Structures using Quinodimethanes and Isobenzofurans: Approaches to the Podophyllins

Novel routes to 1-aryl-5,6-dialkoxy-1,3-dihydrobenzothiophene 2,2-dioxides (13) and to the corresponding benzofuran (8) have been developed; these species yield quinodimethanes (12) via thermal extrusion of SO2 and isobenzofurans (5c) in an acid-cat