55545-80-7 Usage
Uses
Used in Pharmaceutical Synthesis:
2-(Dimethylamino)-6-(trifluoromethyl)-4-pyrimidinol is utilized as an intermediate in the synthesis of pharmaceutical products. Its presence in the molecular structure of certain drugs can contribute to their therapeutic effects, potentially enhancing their efficacy and selectivity.
Used in Agricultural Chemicals:
In the agricultural sector, 2-(Dimethylamino)-6-(trifluoromethyl)-4-pyrimidinol serves as an intermediate in the production of agricultural chemicals. Its incorporation into these products may improve their performance in pest control and crop protection.
Used in Fluorescent Probes for Metal Ion Detection:
2-(Dimethylamino)-6-(trifluoromethyl)-4-pyrimidinol has been studied for its potential use as a fluorescent probe for detecting metal ions. Its chemical properties allow it to selectively bind to certain metal ions, making it a valuable tool in analytical chemistry and environmental monitoring.
Used in Organic Electronics and Materials Science:
Due to its distinctive chemical structure and properties, 2-(Dimethylamino)-6-(trifluoromethyl)-4-pyrimidinol may have applications in the field of organic electronics. It could be employed in the development of new materials with improved electronic properties, contributing to advances in electronic devices and technologies.
Check Digit Verification of cas no
The CAS Registry Mumber 55545-80-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,5,4 and 5 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 55545-80:
(7*5)+(6*5)+(5*5)+(4*4)+(3*5)+(2*8)+(1*0)=137
137 % 10 = 7
So 55545-80-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H8F3N3O/c1-13(2)6-11-4(7(8,9)10)3-5(14)12-6/h3H,1-2H3,(H,11,12,14)
55545-80-7Relevant academic research and scientific papers
Synthesis of novel strobilurin-pyrimidine derivatives and their antiproliferative activity against human cancer cell lines
Chai, Baoshan,Wang, Shuyang,Yu, Wenquan,Li, Huichao,Song, Chuanjun,Xu, Ying,Liu, Changling,Chang, Junbiao
supporting information, p. 3505 - 3510 (2013/07/28)
A series of new strobilurin-pyrimidine analogs were designed and synthesized based on the structures of our previously discovered antiproliferative compounds I and II. Biological evaluation with two human cancer cell lines (A549 and HL60) showed that most of these compounds possessed moderate to potent antiproliferative activity. Two potent candidates (8f, IC50 = 2.2 nM and 11d, IC50 = 3.4 nM) were identified with nanomolar activity against leukemia cancer cell line HL60 for further development. This activity represents a 1000- to 2500-fold improvement compared to the parent compounds I and II and is 20- to 30-fold better than the chemotherapy drug, doxorubicin. The present work provides strong incentive for further development of these strobilurin-pyrimidine analogs as potential antitumor agents for the treatment of leukemia.
Some Diazinon Analogues Containing the 4-Trifluoromethyl Group
Gershon, Herman,Clarke, Donald D.,Grefig, Anthony T.,Anderson, Thomas E.
, p. 289 - 292 (2007/10/02)
Diazinon analogues were prepared containing trifluoromethyl in place of the 4-methyl group and methylthio (2a), amino (2b), dimethylamino (2c), methylphenylamino (2d), or isopropyl (2e) in position 2 of the pyrimidine ring.The most active analogue (2b) wa
