55561-02-9

Basic information

• Product Name: trimethylthioacetic S-acid
• Synonyms: trimethylthioacetic S-acid;2,2-Dimethylpropanethioic acid;2,2-Dimethylthiopropionic acid;Thiopivalic acid,97%;2,2-dimethylpropanethioic S-acid
• CAS NO: 55561-02-9
• Molecular Formula: C₅H₁₀OS
• Molecular Weight: 118.1973
• EINECS: 259-708-5
• Mol File: 55561-02-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 126 °Cat760mmHg
• Flash Point: 23.9 °C
• Appearance: /
• Density: 0.966 g/cm³
• Vapor Pressure: 11.9mmHg at 25°C
• Refractive Index: 1.453
• PKA: 5.05±0.10(Predicted)
• CAS DataBase Reference: trimethylthioacetic S-acid(CAS DataBase Reference)
• NIST Chemistry Reference: trimethylthioacetic S-acid(55561-02-9)
• EPA Substance Registry System: trimethylthioacetic S-acid(55561-02-9)

Safety Data

• RIDADR: 2920
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 55561-02-9(Hazardous Substances Data)

Usage

General Description

Trimethylthioacetic S-acid is a small molecule chemical compound with the molecular formula C5H10OS. It is a thiol derivative that contains a thioacetic acid functional group, with three methyl groups attached to the carbon atom. trimethylthioacetic S-acid is used in organic synthesis as a reagent for the preparation of various sulfur-containing compounds. It is also known for its strong odor, which has been described as similar to that of rotten eggs. Trimethylthioacetic S-acid has been studied for its potential pharmaceutical applications, including as a potential antiviral and antimicrobial agent. Despite its foul smell, it continues to be a valuable compound in the field of organic chemistry.

InChI:InChI=1/C5H10OS/c1-5(2,3)4(6)7/h1-3H3,(H,6,7)

Upstream product

• 3282-30-2 pivaloyl chloride 
• 62-55-5 thioacetamide 
• 75-98-9 Trimethylacetic acid 

Downstream Products

• 120226-49-5 N-(4-methoxybenzyl)pivalamide 
• 6625-74-7 N-pivaloylaniline 
• 70414-49-2 2,2-dimethyl-1-morpholinopropan-1-one 
• 220720-99-0 bis(μ-1-phenyl-1,3-butanedionato)di-μ3-oxo-di-μ-sulfido-bis(μ-thiotrimethylacetato)tetraoxotetramolybdenum(V) 
• 600-57-7 (8S,9S,10R,11S,13S,14S,17S)-17-Acetyl-11-hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one 
• 124044-25-3 2,2-Dimethyl-thiopropionic acid S-[(Z)-(R)-7-(tert-butyl-diphenyl-silanyloxymethyl)-6-hydroxy-3,3-dimethyl-10-trimethylsilanyl-dec-7-ene-4,9-diynyl] ester 
• 124044-25-3 2,2-Dimethyl-thiopropionic acid S-[(Z)-7-(tert-butyl-diphenyl-silanyloxymethyl)-6-hydroxy-3,3-dimethyl-10-trimethylsilanyl-dec-7-ene-4,9-diynyl] ester 
• 153121-88-1 S-(2-hydroxyethyl) 2,2-dimethylpropanethioate 
• 77853-18-0 2,2-Dimethyl-thiopropionic acid S-[1-(2,2-dimethyl-propionylsulfanyl)-2,3-diphenyl-cycloprop-2-enyl] ester 

Relevant articles and documents

A simple method for the conversion of carboxylic acids into thioacids with Lawesson's reagent

A one-step protocol for the conversion of carboxylic acids to thioesters, using Lawesson's Reagent, has been developed.

A facile synthesis of thioacids by hydrolysis of 1-(acylthio)ethaniminium chlorides

A facile method for the preparation of thioacids in moderate to good yields has been developed by hydrolysis of 1-(acylthio)ethaniminium chlorides under a liquid-liquid two phase system consisting of benzene and a sodium hydroxide aqueous solution at room temperature. We have achieved facile preparation of these compounds without use of toxic compounds such as hydrogen sulfide.