55561-02-9

Basic information

• Product Name: trimethylthioacetic S-acid
• Synonyms: trimethylthioacetic S-acid;2,2-Dimethylpropanethioic acid;2,2-Dimethylthiopropionic acid;Thiopivalic acid,97%;2,2-dimethylpropanethioic S-acid
• CAS NO: 55561-02-9
• Molecular Formula: C₅H₁₀OS
• Molecular Weight: 118.1973
• EINECS: 259-708-5
• Mol File: 55561-02-9.mol

Chemical Properties

• Boiling Point: 126 °Cat760mmHg
• Flash Point: 23.9 °C
• Appearance: /
• Density: 0.966 g/cm³
• Vapor Pressure: 11.9mmHg at 25°C
• Refractive Index: 1.453
• PKA: 5.05±0.10(Predicted)
• CAS DataBase Reference: trimethylthioacetic S-acid(CAS DataBase Reference)
• NIST Chemistry Reference: trimethylthioacetic S-acid(55561-02-9)
• EPA Substance Registry System: trimethylthioacetic S-acid(55561-02-9)

Safety Data

• RIDADR: 2920
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 55561-02-9(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Trimethylthioacetic S-acid is utilized as a reagent for the preparation of various sulfur-containing compounds, contributing to the diversity of organic chemistry.
Used in Pharmaceutical Applications:
Trimethylthioacetic S-acid is studied for its potential as an antiviral and antimicrobial agent, indicating its possible use in the development of new treatments for infectious diseases.
Used in Chemical Research:
Due to its unique properties, trimethylthioacetic S-acid serves as a valuable compound in chemical research, aiding in the exploration of new chemical reactions and the synthesis of novel compounds.

InChI:InChI=1/C5H10OS/c1-5(2,3)4(6)7/h1-3H3,(H,6,7)

Upstream product

• 3282-30-2 pivaloyl chloride 
• 62-55-5 thioacetamide 
• 75-98-9 Trimethylacetic acid 

Downstream Products

• 77853-18-0 2,2-Dimethyl-thiopropionic acid S-[1-(2,2-dimethyl-propionylsulfanyl)-2,3-diphenyl-cycloprop-2-enyl] ester 
• 6625-74-7 N-pivaloylaniline 
• 70414-49-2 2,2-dimethyl-1-morpholinopropan-1-one 
• 600-57-7 (8S,9S,10R,11S,13S,14S,17S)-17-Acetyl-11-hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one 
• 124044-25-3 2,2-Dimethyl-thiopropionic acid S-[(Z)-(R)-7-(tert-butyl-diphenyl-silanyloxymethyl)-6-hydroxy-3,3-dimethyl-10-trimethylsilanyl-dec-7-ene-4,9-diynyl] ester 
• 124044-25-3 2,2-Dimethyl-thiopropionic acid S-[(Z)-7-(tert-butyl-diphenyl-silanyloxymethyl)-6-hydroxy-3,3-dimethyl-10-trimethylsilanyl-dec-7-ene-4,9-diynyl] ester 
• 120226-49-5 N-(4-methoxybenzyl)pivalamide 
• 153121-88-1 S-(2-hydroxyethyl) 2,2-dimethylpropanethioate 
• 31172-06-2 Phenyl-pivaloyl-disulfid 

Relevant articles and documents

A simple method for the conversion of carboxylic acids into thioacids with Lawesson's reagent

A one-step protocol for the conversion of carboxylic acids to thioesters, using Lawesson's Reagent, has been developed.

Preparation of para-terphenylylalkanethiols with different chain lengths

Terphenylylalkanethiols with different chain length were synthesized using palladium-catalyzed cross-coupling reactions. While the thiols with two and three methylene groups were obtained via photoaddition of thiopivalic acid to the respective alkenes, the longer terphenylylalkanethiols were synthesized by two consecutive Kumada cross-coupling reactions followed by a Mitsunobu reaction for the introduction of the sulfur functionality. Georg Thieme Verlag Stuttgart.

A facile synthesis of thioacids by hydrolysis of 1-(acylthio)ethaniminium chlorides

A facile method for the preparation of thioacids in moderate to good yields has been developed by hydrolysis of 1-(acylthio)ethaniminium chlorides under a liquid-liquid two phase system consisting of benzene and a sodium hydroxide aqueous solution at room temperature. We have achieved facile preparation of these compounds without use of toxic compounds such as hydrogen sulfide.

Facile Catalytic Conversion of Carboxylic Acids into Thiocarboxylic S-Acids by the Ph3SbO/P4S10 System

Thiocarboxylic S-acids 2 are readily prepared by direct sulfuration of the corresponding carboxylic acids 1 catalyzed by Ph3SbO/P4S10 under mild conditions.