55568-06-4Relevant articles and documents
Impurity of gabapentin and preparation method thereof
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Paragraph 0029; 0046-0047; 0050-0051, (2021/11/27)
The invention provides a new unknown impurity compound (VII) for gabapentin and a preparation method thereof, wherein the chemical name is 2 - [1 - [(1, 3 - diaza -2 - aza-spiro [4.5] dec -2 -yl) methyl] cyclohexyl] - acetic acid. The impurities are prepared by reacting (1 -) cyclohexanecarboxylic acid (VI) with gabapentin (I), and the synthetic route is as shown below. The impurities thus obtained can be used to support the quality studies of the impurities and to support the process improvement of gabapentin with regard to the control of the impurities.
Methods and compositions for terpenoid tricycloalkane synthesis
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Page/Page column 48; 53; 54; 84; 85, (2019/05/26)
In one aspect, the disclosure relates to methods for preparation of intermediates useful for the preparation of terpenoid cores. In a further aspect, the disclosed methods pertain to the preparation of compounds comprising a terpenoid core or scaffold, su
An Enyne Cope Rearrangement Enables Polycycloalkane Synthesis from Readily Available Starting Materials
Scott, Sarah K.,Grenning, Alexander J.
supporting information, p. 8125 - 8129 (2017/06/30)
Cyclohexanone-derived Knoevenagel adducts (cyclohexylidenemalononitriles) and two different propargyl electrophiles serve as carbon sources for assembling diverse 6/7/5 tricycloalkanes, a common terpenoid framework. The sequence involves three unique reac
