55568-06-4

Upstream product

• 108-94-1 cyclohexanone 
• 105-34-0 methyl 2-cyanoacetate 
• 67-56-1 methanol 

Downstream Products

• 59061-91-5 Cyanglyoxylsaeuremethylester-(p-chlor-phenylhydrazon) 
• 73219-36-0 5-(2-cyano-2-cyclohexylidene-ethyl)-furan-2-carboxylic acid methyl ester 
• 74693-42-8 5-{2-Cyano-1-[5-((E)-2-cyano-2-cyclohexyl-vinyl)-furan-2-carbonyl]-2-cyclohexylidene-ethyl}-furan-2-carboxylic acid methyl ester 
• 104417-72-3 [2,6-Bis-(bis-methylsulfanyl-methylene)-cyclohexylidene]-cyano-acetic acid methyl ester 
• 167421-34-3 4-Cyano-3,3-dimethyl-1-phenyl-2-aza-spiro[4.5]dec-1-ene-4-carboxylic acid methyl ester 
• 4172-99-0 (1-cyanocyclohexyl)acetonitrile 
• 4355-11-7 1,1-cyclohexanediacetic acid 
• 60142-96-3 H-Gpn-OH 
• 64744-50-9 gabapentin-lactam 
• 133481-09-1 (1-cyanocyclohexyl)-acetic acid 

Relevant academic research and scientific papers

Impurity of gabapentin and preparation method thereof

The invention provides a new unknown impurity compound (VII) for gabapentin and a preparation method thereof, wherein the chemical name is 2 - [1 - [(1, 3 - diaza -2 - aza-spiro [4.5] dec -2 -yl) methyl] cyclohexyl] - acetic acid. The impurities are prepared by reacting (1 -) cyclohexanecarboxylic acid (VI) with gabapentin (I), and the synthetic route is as shown below. The impurities thus obtained can be used to support the quality studies of the impurities and to support the process improvement of gabapentin with regard to the control of the impurities.

Preparation method of 1-cyanocyclohexyl acetonitrile

The invention provides a method for preparing 1-cyanocyclohexyl acetonitrile by a 'one-pot method', which mainly comprises the following steps: reacting cyclohexanone with alkyl cyanoacetate in the presence of weak base salt and optional acid in a proper organic solvent; after the reaction is completed, adding cyanide, water and a phase transfer catalyst into the reaction system without treatment,and continuing the reaction to obtain 1-cyanocyclohexyl acetonitrile. According to the 1-cyanocyclohexyl acetonitrile obtained by the method, the purity and yield of the product are greatly improved,and the method is low in production cost, simple to operate and suitable for industrial production.

Methods and compositions for terpenoid tricycloalkane synthesis

In one aspect, the disclosure relates to methods for preparation of intermediates useful for the preparation of terpenoid cores. In a further aspect, the disclosed methods pertain to the preparation of compounds comprising a terpenoid core or scaffold, su

Knoevenagel condensation catalyzed by novel Nmm-based ionic liquids in water

A series of novel N-methyl morpholine (Nmm) based ionic liquids with 1,2-propanediol group were synthesized and used as catalysts for Knoevenagel condensation at room temperature in water. Under the effect of the catalyst, various aldehydes or aliphatic ketones could react with a wide range of activated methylene compounds well, including malononitrile, alkyl cyanoacetate, cyanoacetamide, β-diketone, barbituric acid, 2-arylacetonitrile and thiazolidinedione. Furthermore, most of the products could be separated just by filtrating and washing with water. Additionally, the catalyst is recyclable and applicable for the large-scale synthesis.

An Enyne Cope Rearrangement Enables Polycycloalkane Synthesis from Readily Available Starting Materials

Cyclohexanone-derived Knoevenagel adducts (cyclohexylidenemalononitriles) and two different propargyl electrophiles serve as carbon sources for assembling diverse 6/7/5 tricycloalkanes, a common terpenoid framework. The sequence involves three unique reac

A PROCESS FOR THE PREPARATION OF GABAPENTIN

The present invention provides an improved process for the preparation of a compound of formula (I),

Facile metal free regioselective transfer hydrogenation of polarized olefins with ammonia borane

Transfer hydrogenation of polarized olefins bearing strongly electron-withdrawing groups on one side of the double bond was achieved with ammonia borane under mild conditions without using a catalyst. Mechanistic studies proved the character of the direct H transfers proceeding stepwise with a unique hydroboration intermediate and hydride before proton transfer.

Novel cyclopropyl β-amino acid analogues of pregabalin and gabapentin that target the α2-δ protein

As part of a program aimed at generating compounds with affinity for the α2-δ subunit of voltage-gated calcium channels, several novel β-amino acids were prepared using an efficient nitroalkane-mediated cyclopropanation as a key step. Depending

Cyclopropyl beta-amino acid derivatives

This invention relates to novel cyclopropyl β-amino acids derivatives of the formula wherein R1 through R4 are defined as in the specification, pharmaceutical compositions containing them and their use for the treatment of various ce

TETRAZOLE AND OXADIAZOLONE SUBSTITUTED β-AMINO ACID DERIVATIVES

This invention relates to novel tetrazole and oxadiazalone β-amino acids derivatives of the formula (I, II), wherein G is (III, IV) wherein R1 through R4 are defined as in the specification, pharmaceutical compositions containing the