55579-52-7

Upstream product

• 55579-74-3 5-(2,6-dichlorophenyl)cyclohexane-1,3-dione 
• 552-89-6 2-nitro-benzaldehyde 
• 81559-89-9 4-(2,6-dichlorophenyl)-3-buten-2-one 
• 83-38-5 2,6-dichlorobenzaldehyde 

Downstream Products

• 144128-39-2 7-Chloro-3-(2,6-dichloro-phenyl)-1-[(E)-3-dimethylamino-propylimino]-10-hydroxy-1,3,4,10-tetrahydro-2H-acridin-9-one 

Relevant academic research and scientific papers

Synthesis and Antimalarial Properties of 1-Imino Derivatives of 7-Chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and Related Structures

To improve upon the activity and properties of the 3-aryl-7-chloro-3,4-dihydro-1,9(2H,10H)-acridinediones, a variety of 1-imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and primates.Among structural modifications prepared, including N10-alkyl and C2-substituted analogs, removal of the C9 oxygen, and introduction of an imino side chain at C9, the imines of the N10-H acridinediones were the most active compounds obtained.The imino derivative of7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)-acridinedione (9aa) proved to be highly active in advanced studies in primates.

10-Hydroxy-3,4-dihydroacridine-1,9(2H,10H)-diones: a new group of malaricidal and coccidiostatic compounds

2-Nitrobenzaldehydes and 1,3-cyclohexanediones condense in a mixture of hydrocholic acid and glacial acetic acid to 10-hydroxy-3,4-dihydroacridine-1,9(2H,10H)-diones. Many compounds of this group reveal a pronounced coccidiostatic and malaricidal effect i