55581-61-8

Basic information

• Product Name: 3-Benzofurancarboxaldehyde, 2-methyl-
• Synonyms: 3-Benzofurancarboxaldehyde, 2-methyl-
• CAS NO: 55581-61-8
• Molecular Formula: C₁₀H₈O₂
• Molecular Weight: 160.17
• Mol File: 55581-61-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Benzofurancarboxaldehyde, 2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Benzofurancarboxaldehyde, 2-methyl-(55581-61-8)
• EPA Substance Registry System: 3-Benzofurancarboxaldehyde, 2-methyl-(55581-61-8)

Safety Data

• Hazardous Substances Data: 55581-61-8(Hazardous Substances Data)

Upstream product

• 4265-25-2 2-methylbenzofuran 
• 68-12-2 N,N-dimethyl-formamide 
• 10025-87-3 trichlorophosphate 
• 271-89-6 1-benzofurane 
• 4265-16-1 2-formylbenzo[b]furan 
• 4885-02-3 Dichloromethyl methyl ether 

Downstream Products

• 3782-00-1 2,3-dimethylbenzofuran 
• 138552-76-8 9a-methyl-N-phenyl-1,2,3,9a-tetrahydrobenzofuro<2,3-c>pyridazine-1,2-dicarboximide 
• 138552-58-6 2-methyl-3-vinylbenzofuran 

Relevant articles and documents

NOVEL COMPOUNDS AND THEIR USE

The present invention provides compounds of the general formula (I) or a pharmaceutically acceptable prodrugs, salts and/or solvates thereof, wherein LHS is selected from the group consisting of LHSa and LHSb And wherein, the asterisk (*) marks the point of attachment; These compounds exhibit antibacterial activity against Gram-negative and Gram-positive bacteria, especially S. aureus, E. coli, K. pneumoniae and A. baumannii. Pharmaceutical compositions containing these compounds, therapeutic uses thereof and methods for manufacturing the same are also provided.

Synthesis of Chiral Polycyclic Tetrahydrocarbazoles by Enantioselective Aminocatalytic Double Activation of 2-Hydroxycinnamaldehydes with Dienals

An efficient aminocatalytic enantioselective double-activation strategy has been developed that combines several different aminocatalytic modes in a cascade process, such as iminium ion, vinylogous iminium ion, trienamine, and dienamine activations. By using this strategy, 2-hydroxycinnamaldehydes worked well with various dienals via [4 + 2] cycloaddition and the oxa-Michael reaction-initiated cascade, respectively, leading to chiral polycyclic tetrahydrocarbazole and chromane derivatives with excellent diastereo- and enantioselectivities.

Cyclopenta[b]annulation of Heteroarenes by Organocatalytic γ′[C(sp3)?H] Functionalization of Ynones

A new approach for the cyclopenta[b]annulation of heteroarenes through metal-free and directing-group-free γ′[C(sp3)?H] functionalization and intramolecular hydroalkylation of ynones has been developed. In an unprecedented event, nucleophilic addition of an organophosphine to the designed ynones triggers γ′[C(sp3)?H] functionalization, leading to the formation of heteroaryl-based ortho-quinodimethane (oQDM) intermediates that undergo carbocyclization to provide cyclopentannulated heteroarenes in good yields and excellent stereoselectivities. Deuterium-labeling experiments substantiated the proposed reaction mechanism as well as the speculated epimerization.