3782-00-1Relevant articles and documents
Rhodium-Catalyzed Intermolecular Cyclopropanation of Benzofurans, Indoles, and Alkenes via Cyclopropene Ring Opening
Jeyaseelan, Rubaishan,Lautens, Mark,Ross, Rachel J.
supporting information, (2020/06/29)
The generation of metal carbenoids via ring opening of cyclopropenes by transition metals offers a simple entry into highly reactive intermediates. Herein, we describe a diastereoselective intermolecular rhodium-catalyzed cyclopropanation of heterocycles and alkenes using cyclopropenes as carbene precursors with a low loading of a commercially available rhodium catalyst. The reported method is scalable and could be performed with catalyst loadings as low as 0.2 mol %, with no impact to the reaction yield or selectivity.
Titanium tetrachloride promoted cyclodehydration of aryloxyketones: Facile synthesis of benzofurans and naphthofurans with high regioselectivity
Zhang, Qiu,Luo, Juan,Wang, Bingqiao,Xiao, Xiaoqin,Gan, Zongjie,Tang, Qiang
supporting information, p. 1337 - 1340 (2019/04/16)
An efficient and facile method for the synthesis of a broad series of benzofurans and naphthofurans is described. The direct intramolecular cyclodehydration of aryloxyketones in the presence of titanium tetrachloride affords the corresponding benzofurans and naphthofurans with good regioselectivity and yields.
In order to phenol and α - halo as raw material synthetic benzofuran derivatives (by machine translation)
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Paragraph 0060; 0061; 0062; 0063, (2019/04/14)
The present invention to provide a phenol and α - halo as raw materials, the role of titanium tetrachloride in the reaction of the next step high-efficient method for preparing benzofuran derivative, namely under protection of inert gas, adding phenol to and [...], then heating and stirring to reflux then adding titanium tetrachloride, finally dropping into the α - halo and [...] mixed solution, after the reaction is completed after the separation and purification to obtain the benzofuran derivatives. The synthesizing method of the invention, raw materials are easy, low cost, mild reaction conditions, the operation is simple and easy to control, less side reaction, after treatment is simple, and the product yield is high, production cost is greatly reduced, with better economic benefits, is suitable for the industrial large-scale production. (by machine translation)
