556038-63-2

Upstream product

• 556038-74-5 methanesulfonic acid 3,5-dibromo-4-iodophenyl ester 
• 556038-48-3 (4S)-2-benzyloxy-4-methoxycarbonyl-4-methyl-5-oxo-4,5-dihydrooxazole 
• 556038-43-8 3,5-dibromo-4-iodophenol benzyl ether 
• 556038-78-9 2-benzyloxycarbonyloamino-2-methylmalonic acid dimethyl ester 
• 556038-61-0 (2S)-2-(4-benzyloxy-2,6-dibromophenyl)-3-nitropropan-1-ol 
• 556038-77-8 (2S)-N-(2-nitrobenzenesulfonyl)-3-amino-2-(4-benzyloxy-2,6-dibromophenyl)-propanol 
• 556038-47-2 (3S)-1-benzyl-6-benzyloxy-4-bromo-3-(tert-butyldimethylsilanyloxymethyl)indoline 
• 556038-60-9 (1S,2S,3S)-3-(4-benzyloxy-2,6-dibromophenyl)-4-nitro-1-phenylbutane-1,2-diol 
• 556038-45-0 (4S,5S)-4-[(1S)-1-(4-benzyloxy-2,6-dibromophenyl)-2-nitroethyl]-2,2-dimethyl-5-phenyl-[1,3]dioxolane 
• 556038-46-1 (2S)-3-benzylamino-2-(4-benzyloxy-2,6-dibromophenyl)-propan-1-ol 
• 556038-62-1 (3S)-1-benzyl-6-benzyloxy-4-bromo-3-hydroxymethylindoline 
• 556038-79-0 (2R)-2-benzyloxycarbonylamino-2-methylmalonic acid monomethyl ester 
• 556038-73-4 methanesulfonic acid 4-amino-3,5-dibromophenyl ester 
• 556038-75-6 3,5-dibromo-4-iodophenyjl 

Downstream Products

• 556038-65-4 (2R,8S)-4-benzyloxy-8-(tert-butyldimethylsilanyloxymethyl)-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-1,2,3,6,7,8-hexahydro-3,6-diaza-as-indacene-2,3-dicarboxylic acid 3-benzyl ester 2-methyl ester 
• 556038-67-6 (2R,8S)-4-benzyloxy-8-methanesulfonyloxymethyl-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-1,2,3,6,7,8-hexahydro-3,6-diaza-as-indacene-2,3-dicarboxylic acid 3-benzyl ester 2-methyl ester 
• 556038-66-5 (2R,8S)-4-benzyloxy-8-hydroxymethyl-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-1,2,3,6,7,8-hexahydro-3,6-diaza-as-indacene-2,3-dicarboxylic acid 3-benzyl ester 2-methyl ester 
• 556038-64-3 (2R,8S)-4-benzyloxy-8-(tert-butyldimethylsilanyloxymethyl)-2-methyl-1-oxo-1,2,3,6,7,8-hexahydro-3,6-diaza-as-indacene-2,3,6-tricarboxylic acid 3-benzyl ester 2-methyl ester 6-(2,2,2-trichloroethyl) ester 
• 556038-51-8 (2R,8S)-4-benzyloxy-8-(tert-butyldimethylsilanyloxymethyl)-2-methyl-1-oxo-1,2,3,6,7,8-hexahydro-3,6-diaza-as-indacene-2,3-dicarboxylic acid 3-benzyl ester 2-methyl ester 
• 118292-34-5 duocarmycin A 
• 556038-50-7 (2R,8S)-6-benzyl-4-benzyloxy-8-(tert-butyldimethylsilanyloxymethyl)-2-methyl-1-oxo-1,2,3,6,7,8-hexahydro-3,6-diaza-as-indacene-2,3-dicarboxylic acid 3-benzyl ester 2-methyl ester 

Relevant academic research and scientific papers

Total synthesis of the duocarmycins

The total synthesis of (+)-duocarmycin A and SA through a common indoline intermediate is described. The key reactions include selective lithiation of a 2,6-dibromoiodobenzene derivative and diastereoselective addition to a chiral nitroalkene, copper-mediated aryl amination, and addition of aryllithium to azlactones. Copyright