556038-73-4Relevant academic research and scientific papers
Total synthesis of dictyodendrin A and B
Okano, Kentaro,Fujiwara, Hideto,Noji, Toshiharu,Fukuyama, Tohru,Tokuyama, Hidetoshi
supporting information; experimental part, p. 5925 - 5929 (2010/10/03)
(Figure Presented) In-do-line of fire: A highly efficient total synthesis of the title compounds features a novel benzyne-mediated one-pot indoline formation/cross-coupling sequence for the construction of a highly substituted key indoline intermediate. The peripheral substituents were then introduced onto the intermediate in a modular fashion to complete the total syntheses of dictyodendrin A and B.
Total synthesis of the duocarmycins
Yamada, Ken,Kurokawa, Toshiki,Tokuyama, Hidetoshi,Fukuyama, Tohru
, p. 6630 - 6631 (2007/10/03)
The total synthesis of (+)-duocarmycin A and SA through a common indoline intermediate is described. The key reactions include selective lithiation of a 2,6-dibromoiodobenzene derivative and diastereoselective addition to a chiral nitroalkene, copper-mediated aryl amination, and addition of aryllithium to azlactones. Copyright
