55604-95-0Relevant articles and documents
Aziridine-mediated ligation and site-specific modification of unprotected peptides
Dyer, Frank Brock,Park, Chung-Min,Joseph, Ryan,Garner, Philip
supporting information; experimental part, p. 20033 - 20035 (2012/01/31)
A synthesis of aziridine-containing peptides via the Cu(II)-promoted coupling of unprotected peptide thioacids and N-H aziridine-2-carbonyl peptides is reported. The unique reactivity of the resulting N-acylated aziridine-2-carbonyl peptides facilitates t
Synthesis and NMR spectroscopic studies of optically active derivatives of γ-aminobutenoic acids and 2-amino-pyrrolin-4-ones
Petroliagi,Igglessi-Markopoulou
, p. 917 - 922 (2007/10/03)
An efficient method for the preparation of optically active derivatives of γ-amino-butenoic acids and their cyclic derivatives, 2-amino-pyrrolin-4-ones, from α-amino acids is described. Partial racemization accompanies the formation of initial unsaturated
Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin
Dubowchik, Gene M.,Firestone, Raymond A.
, p. 3343 - 3346 (2007/10/03)
A series of lysosomal protease-sensitive peptides attached to doxorubicin (DOX) was prepared as model substrates for internalizing anticancer immunoconjugates and potential antimetastasis prodrugs. Rates of cathepsin B-mediated release of free drug was measured for each, and human plasma stabilities for representative examples.
