556050-49-8

Usage

InChI:InChI=1/C23H16F17NO5/c24-16(25,17(26,27)18(28,29)19(30,31)20(32,33)21(34,35)22(36,37)23(38,39)40)9-1-2-11-3-5-12(6-4-11)10-45-15(44)46-41-13(42)7-8-14(41)43/h3-6H,1-2,7-10H2

Upstream product

• 75-44-5 phosgene 
• 82911-72-6 dicyclohexylamine salt of N-hydroxysuccinimide 
• 356055-77-1 (4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)phenyl)methanol 
• 495388-41-5 4-(1H,1H,2H,2H-perfluorodecyl)benzyl chloroformate 

Downstream Products

• 556050-59-0 (S)-3-phenyl-2-[4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)benzyloxycarbonylamino]propionic acid 
• 1371577-92-2 (S)-5-(3,3-dimethylguanidino)-2-((((4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)-benzyl)oxy)carbonyl)amino)pentanoic acid 
• 1418000-63-1 N-(1H,1H,2H,2H-perfluorodecyl)-benzyloxycarbonyl-5-aminopentanol 
• 1418000-64-2 N-(benzyl)-(1H,1H,2H,2H-perfluorodecyl)-benzyloxycarbonyl-5-aminopentanol 

Relevant academic research and scientific papers

NEW FLUOROUS TAGGING AND SCAVENGING REACTANTS AND METHODS OF SYNTHESIS AND USE THEREOF

The present invention includes methods and compositions for increasing the fluorous nature of an organic compound by reacting it with at least one fluorous compound to produce a fluorous tagged organic compound. The increased fluorous nature of the fluorous tagged organic compound can then be utilized to separate the fluorous organic compound from untagged reagents, reactants, catalysts and/or products derived therefrom. The resultant fluorous tagged organic compound can be subjected to subsequent chemical transformations, wherein the fluorous nature of the tagged compound is utilized to increase the ease of separation of the fluorous tagged organic compound from untagged reagents, reactants, catalysts and/or products derived therefrom, after each chemical transformation. The chemical transformations result in a second fluorous tagged organic compound wherein the fluorous nature of the second fluorous tagged organic compound can then be reduced by removing the fluorous group therefrom, thereby producing a second organic compound that may be employed as a pharmaceutical compound or intermediate, or a combinatorial library component.

Synthesis and reactions of fluorous carbobenzyloxy (fCbz) derivatives of α-amino acids

Fluorous carbobenzyloxy (FCbz) reagents RfCH2CH2C6H4CH2 OC(O)OSu (where Su is succinimidoyl and Rf is C6F13 and C8F17) have been used to make su