556104-48-4Relevant academic research and scientific papers
Enantioselective total synthesis of ustiloxin D
Tanaka, Hiroko,Sawayama, Andrew M.,Wandless, Thomas J.
, p. 6864 - 6865 (2003)
Ustiloxin D and phomopsin A are potent antimitotic agents that bind to tubulin and interfere with cellular microtubule function. A synthetic strategy has been developed to allow access to both of the natural products as well as a variety of variants of th
Total synthesis of ustiloxin D and considerations on the origin of selectivity of the asymmetric allylic alkylation
Sawayama, Andrew M.,Tanaka, Hiroko,Wandless, Thomas J.
, p. 8810 - 8820 (2007/10/03)
As part of investigations into cell cycle checkpoint inhibitors, an asymmetric synthesis of the antimitotic natural product, ustiloxin D, has been completed. A salen-Al-catalyzed aldol reaction was employed to construct a chiral oxazoline 9 (99% yield, 98
