55611-39-7Relevant articles and documents
A biocatalytic cascade for the amination of unfunctionalised cycloalkanes
Tavanti, Michele,Mangas-Sanchez, Juan,Montgomery, Sarah L.,Thompson, Matthew P.,Turner, Nicholas J.
supporting information, p. 9790 - 9793 (2017/12/08)
Here we describe a one-pot, three-enzyme, cascade involving a cytochrome P450 monooxygenase, an alcohol dehydrogenase and a reductive aminase for the synthesis of secondary amines from cycloalkanes. Amine product concentrations of up to 19.6 mM were achieved. The preparative scale amination of cyclohexane was also demonstrated with a space-time yield of 2 g L-1 d-1.
Secondary amine formation from reductive amination of carbonyl compounds promoted by lewis acid using the InCl3ZEt3SiH system
Lee, On-Yi,Law, Ka-Lun,Yang, Dan
supporting information; experimental part, p. 3302 - 3305 (2009/11/30)
A robust and reliable method has been developed for reductive amination of primary amines with various aldehydes and ketones using Zn(ClO4) 2.6H20 as a catalyst. [In-H] generated in situ via a combination of InCl3 and Et3SiH is employed as an effective reducing system. A variety of secondary amines can be synthesized in a one-pot procedure in excellent yields.
Lewis Acid-Promoted 3-Aza-Cope Rearrangement of N-Alkyl-N-allylenamines
Cook, Gregory R.,Barta, Nancy S.,Stille, John R.
, p. 461 - 467 (2007/10/02)
The 3-aza-Cope rearrangement of the N-alkyl-N-allylenamines derived from isobutyraldehyde, which proceeds thermally at 250 deg C, has been accelerated by a variety of electrophilic reagents to give γ,δ-unsaturated imines.Protic acids, such as HCl (0.5 equ
