55661-34-2

Usage

Uses

Used in Research and Scientific Applications:
1H-Benzimidazole-1-ethanamine(9CI) is used as a research chemical for various scientific applications. Its unique structure and properties make it a valuable compound for studying the effects of benzoimidazoles in different chemical reactions and processes. The presence of the ethylamine group may also contribute to its potential use in the synthesis of other compounds, making it a versatile building block in organic chemistry.
Used in Pharmaceutical Synthesis:
1H-Benzimidazole-1-ethanamine(9CI) is used as an intermediate in the synthesis of pharmaceutical compounds. Its nitrogen-containing ring and ethylamine group can be utilized in the development of new drugs, particularly those that target specific biological receptors or enzymes. 1H-Benzimidazole-1-ethanamine(9CI)'s reactivity and potential biological activity make it a promising candidate for use in the creation of novel therapeutic agents.
Used in Chemical Synthesis:
1H-Benzimidazole-1-ethanamine(9CI) is used as a reagent in the synthesis of various chemical compounds. Its aromatic nature and the presence of the ethylamine group make it a useful building block for the creation of new molecules with potential applications in a wide range of industries, including materials science, electronics, and agriculture. 1H-Benzimidazole-1-ethanamine(9CI)'s versatility in chemical reactions allows for the exploration of new synthetic pathways and the development of innovative products.

InChI:InChI=1/C9H11N3/c10-5-6-12-7-11-8-3-1-2-4-9(8)12/h1-4,7H,5-6,10H2

Upstream product

• 64-18-6 formic acid 
• 128995-76-6 N-(2-aminophenyl)ethylenediamine 
• 4414-84-0 3-(1H-benzo[d]imidazol-1-yl)propanenitrile 
• 4414-74-8 2-(1H-benzo[d]imidazol-1-yl)acetonitrile 
• 51-17-2 benzoimidazole 
• 689-98-5 chloroethylamine 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 101285-09-0 N-[2-(2-amino-anilino)-ethyl]-phthalimide 
• 834881-63-9 tert‐butyl (3‐((2‐nitrophenyl)amino)ethyl)carbamate 
• 1493-27-2 ortho-nitrofluorobenzene 
• 51138-16-0 N-(2-nitrophenyl)ethylenediamine 
• 22492-17-7 3-(1H-benzo[d]imidazol-1-yl)propanamide 

Downstream Products

• 99168-05-5 1-(2-methylamino-ethyl)-1H-benzo[d]imidazole 
• 1616961-16-0 N-(2-(1H-benzo[d]imidazol-1-yl)ethyl)-4-(diethylamino)benzamide 
• 99055-78-4 N-(2-benzimidazol-1-yl-ethyl)-formamide 

Relevant academic research and scientific papers

Multitarget Biological Profiling of New Naphthoquinone and Anthraquinone-Based Derivatives for the Treatment of Alzheimer's Disease

Two series of naphthoquinone and anthraquinone derivatives decorated with an aromatic/heteroaromatic chain have been synthesized and evaluated as potential promiscuous agents capable of targeting different factors playing a key role in Alzheimer's disease (AD) pathogenesis. On the basis of the in vitro biological profiling, most of them exhibited a significant ability to inhibit amyloid aggregation, PHF6 tau sequence aggregation, acetylcholinesterase (AChE), and monoamine oxidase (MAO) B. In particular, naphthoquinone 2 resulted as one of the best performing multitarget-directed ligand (MTDL) experiencing a high potency profile in inhibiting β-amyloid (Aβ40) aggregation (IC50 = 3.2 μM), PHF6 tau fragment (91% at 10 μM), AChE enzyme (IC50 = 9.2 μM) jointly with a remarkable inhibitory activity against MAO B (IC50 = 7.7 nM). Molecular modeling studies explained the structure-activity relationship (SAR) around the binding modes of representative compound 2 in complex with hMAO B and hAChE enzymes, revealing inhibitor/protein key contacts and the likely molecular rationale for enzyme selectivity. Compound 2 was also demonstrated to be a strong inhibitor of Aβ42 aggregation, with potency comparable to quercetin. Accordingly, atomic force microscopy (AFM) revealed that the most promising naphthoquinones 2 and 5 and anthraquinones 11 and 12 were able to impair Aβ42 fibrillation, deconstructing the morphologies of its fibrillar aggregates. Moreover, the same compounds exerted a moderate neuroprotective effect against Aβ42 toxicity in primary cultures of cerebellar granule cells. Therefore, our findings demonstrate that these molecules may represent valuable chemotypes toward the development of promising candidates for AD therapy.

Benzocarbazoles heterocyclic compound and its preparation and use (by machine translation)

The present invention provides a class of non-nucleoside anti-viral inhibitors, in particular to such as shown in formula I benzo heterocyclic compound or its pharmaceutically acceptable salt or hydrate, the invention also provides the compound or its pharmaceutically acceptable salt or hydrate of the preparation method. Pharmacological test indicates that the compound or its pharmaceutically acceptable salt or hydrate can effectively inhibit hepatitis b virus DNA replication and hepatitis c virus RNA replication, therefore, the invention also provides the compounds in the preparation of preventing and/or the treatment of viral infections, particularly hepatitis b virus (HBV) infection, hepatitis c virus (HCV) infection of use of the medicament. (by machine translation)

CINNAMIC ACID AMIDE DERIVATIVE

The present invention provides a cinnamic acid amide derivative having an excellent analgesic action. The cinnamic acid amide derivative of the present invention is a compound showing excellent analgesic actions to not only a nociceptive pain model animal but also a neuropathic pain model animal, which is very useful as an agent for treating various pain diseases showing acute or chronic pains or neuropathic pains.

(2-aminoethyl)-N hydrofluorination compd. manufacturing method

PROBLEM TO BE SOLVED: To provide a method for preparing an N-(2-aminoethyl)azole compound, which is a preparation method offering short reaction time, high purification efficiency of a final product, high production efficiency and high safety because a reaction solution undergoes no heat generation or rise of liquid level caused by bubbling. SOLUTION: The method for preparing the N-(2-aminoethyl)azole compound comprises reacting an azole-based compound (A) and an ethylamine derivative (B) having a leaving group at position 2 in the presence of a base (C) in a solvent (D) so as to prepare the N-(2-aminoethyl)azole compound. Here, the ethylamine derivative (B) having the leaving group at position 2 is fed to the reaction system in portions while the reaction system is maintained at 50-200°C. COPYRIGHT: (C)2010,JPOandINPIT

Studies on the novel anti-staphyloccal compound nematophin

A number of analogues of the recently described compound nematophin were prepared and studied for antibacterial activity. The 2-phenyl derivative was found to exhibit exceptional activity against methicillin resistant Staphylococcus aureus (MRSA) whereas the isosteric benzimidazole analogue was much less active. (C) 2000 Elsevier Science Ltd. All rights reserved.