55661-43-3Relevant articles and documents
Tin(IV) chloride-sodium nitrite as a new nitrosating agent for N-nitrosation of amines, amides and ureas under mild and heterogeneous conditions
Celaries, Benoit,Parkanyi, Cyril
, p. 2371 - 2375 (2008/02/03)
We have developed a new method of N-nitrosation of various secondary and tertiary amines, amides and ureas using a mixture of tin(IV) chloride and sodium nitrate. This method leads to a selective, high-yielding and mild heterogeneous N-nitrosation by in situ generation of nitrosyl chloride (NOCl). The reaction can be carried out in several different solvents such as chloroform, dichloromethane, ethers, ethyl acetate and alcohols, at room temperature. Georg Thieme Verlag Stuttgart.
Nitrosourea derivatives
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, (2008/06/13)
Novel nitrosourea derivatives are provided which possess a high level of inhibitory activity against leukemia and tumors and which are therefore useful for pharmaceutical purposes. The compounds have the structure represented by formula (I): STR1 wherein R0 represents --OH or --OCm H2m+1 where m is an integer of 1 to 3 and one of R1, R2, R3 and R4 represents STR2 where X is STR3 or an alkylene group of 1 to 3 carbon atoms, n is an integer of 1 to 3 and Y is the group on the α-carbon atom of an α-amino acid and each of the remaining three represents --OH; or wherein R0 represents STR4 and R1, R2, R3 and R4 each represent --OH; or by formula (II): STR5 wherein X and n have the same meanings as above; and p is an integer of 1 to 5.
A selective synthesis of N-alkyl N-nitrosoureas
Martinez,Oiry,Imbach,Winternitz
, p. 211 - 213 (2007/10/02)
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