55661-42-2

Usage

InChI:InChI=1/C9H9ClN2O4/c10-5-6-11-9(13)16-8-3-1-7(2-4-8)12(14)15/h1-4H,5-6H2,(H,11,13)

Upstream product

• 870-24-6 2-chloroethanamine hydrochloride 
• 7693-46-1 4-Nitrophenyl chloroformate 
• 1943-83-5 2-chloroethyl isothiocyanate 
• 100-02-7 4-nitro-phenol 

Downstream Products

• 100-02-7 4-nitro-phenol 
• 55661-43-3 p-nitrophenyl N-(2-chloroethyl)-N-nitroso-carbamate 

Relevant academic research and scientific papers

Structure-reactivity relationships as probes for the inhibition mechanism of cholesterol esterase by aryl carbamates. I. Steady-state kinetics

For substituted phenyl-N-butyl carbamates (1) and 4-nitrophenyl-N-substituted carbamates (2), linear relationships between values of NH proton chemical shift (δNH), pKa, and logk[OH] and Hammett substituent constant (σ) or Taft subst

Linear free energy relationships of the inhibition of pancreatic cholesterol esterase by 4-nitrophenyl-N-alkylcarbamate

4-Nitrophenyl-N-alkylcarbamates (1) as active site-directed irreversible inhibitors of pancreatic cholesterol esterase are investigated for values of the dissociation constant (K(i)), the carbamylation constant (k2), and the bimolecular rate co

1-Aryl-3-(2-chloroethyl) ureas: Synthesis and in vitro assay as potential anticancer agents

1-Aryl-3-(2-chlorethyl) ureas and 1-aryl-3-nitrose-3-(2-chloroethyl) ureas, derived from 4-phenylbutyric acid and alkylanillines, were synthesized and their cytotoxicity was evaluated on human adenocarcinoma cells in vitro. Methyl 4-[p-[3-(2-chloroethyl)ureido]-phenyl]butyrate, 4-methyl [3-(2-chloroethyl)ureido]benzene, and 4-butyl[3-(2-chloroethyl)ureido]benzene were found to be at least as cytotoxic as 4-[p-[bis-(2-chloroethyl)amino]phenyl]butyric acid (chlorambucil), while their N-nitrose derivatives were inactive.

Nitrosourea derivatives

Novel nitrosourea derivatives are provided which possess a high level of inhibitory activity against leukemia and tumors and which are therefore useful for pharmaceutical purposes. The compounds have the structure represented by formula (I): STR1 wherein R0 represents --OH or --OCm H2m+1 where m is an integer of 1 to 3 and one of R1, R2, R3 and R4 represents STR2 where X is STR3 or an alkylene group of 1 to 3 carbon atoms, n is an integer of 1 to 3 and Y is the group on the α-carbon atom of an α-amino acid and each of the remaining three represents --OH; or wherein R0 represents STR4 and R1, R2, R3 and R4 each represent --OH; or by formula (II): STR5 wherein X and n have the same meanings as above; and p is an integer of 1 to 5.