556801-40-2

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-fluoro-4 nitrophenyl)-4-phenylpiperazine is used as a potential therapeutic agent for mental health disorders due to its interaction with neurotransmitter receptors in the brain, which may affect serotonin and dopamine levels. Its potential antidepressant and anxiolytic properties make it a promising candidate for further research and development in the pharmaceutical industry.
Used in Research and Development:
In the field of research and development, 1-(2-fluoro-4 nitrophenyl)-4-phenylpiperazine serves as a valuable compound for studying the effects of piperazine derivatives on neurotransmitter receptors and their potential role in treating mental health disorders. 1-(2-fluoro-4 nitrophenyl)-4-phenylpiperazine can be used to explore new avenues in drug discovery and development, particularly for conditions such as depression and anxiety.

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 369-34-6 3,4-difluoronitrobenzene 

Downstream Products

• 556801-42-4 (R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate 
• 556801-43-5 (R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl phthalimide 
• 1410082-29-9 (Z)-2-[3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino-2'-[5-(4-chlorophenyl)-3-(4-fluorophenyl)thiazolin-2-yliden]acetohydrazide 
• 1410082-26-6 5-([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)methyl-2-(4-fluoroanilino)-1,3,4-thiadiazole 
• 1410082-25-5 4-(4-fluorophenyl)-5-(([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)methyl)-4H-1,2,4-triazole-3-thiol 
• 1410082-22-2 N-(4-fluorophenyl)-2-(([3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]amino)acetyl)hydrazine carbothioamide 
• 465520-11-0 (S)-N-[[3-(3-fluoro-4-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide 
• 556801-41-3 N-benzyloxycarbonyl-3-fluoro-4-(4-phenylpiperazinyl)aniline 
• 465520-07-4 (R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methanol 
• 735276-50-3 (S)-N-[[3-(3-fluoro-4-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl]amine 
• 478079-57-1 3-fluoro-4-(4-phenylpiperazin-1-yl)aniline 

Relevant academic research and scientific papers

Novel 3-fluoro-4-morpholinoaniline derivatives: Synthesis and assessment of anti-cancer activity in breast cancer cells

Heterocyclic morpholine compounds are well-known for their anti-cancer activity. In this study, novel morpholine and its sulfonamide derivatives were designed and synthesized as potential anti-tumor agents. The new compounds were obtained from amine derivatives via nucleophilic addition reactions, providing the desired products in 70 to 90% yield. The docking analysis was performed for all thirty-one compounds. Out of them, we represent the docking poses for compounds NAM-5 and NAM-7 as representatives. After docking analysis, compounds NAM-5 and NAM- 7 were tested for in vitro antitumor activity against breast cancer cell lines (MCF-7 and MDA-MB-231) and healthy mouse embryonic fibroblast cell line (3T3L-1). Amongst these, sulfonamide group-containing compound NAM-5 showed significant anti-proliferative activity with IC50 of 1.811 μM and 2.143 μM for MCF-7 and MDA-MB-231 cells, respectively. On the other hand, NAM-7 showed good anti-proliferative activity against MCF-7 (IC50 1.883 μM) but slightly lower activity against MDA-MB-231 cells (IC50 4.688 μM). The activity of both the compound was also tested on 3T3L-1 Cell line which showed activity similar to clinically approved anti-cancer drug doxorubicin (DOX). The cell death analysis by flow-cytometry confirmed apoptosis mediated cell death in 3T3L-1, MCF-7 and MDA-MB-231 cells when treated with the NAM-5 and NAM-7, respectively. The results demonstrated that the synthesized sulfonamide derivatives have significant potential as anti-cancer agents and have a substantial importance in cancer therapeutics with favourable safety profile. Structural analysis of docked poses of sulfonamide derivatives attempts to shed light on the structural basis of sulfonamide derivatives based anti-cancer effect.

Benzofuroxan Derivatives as Potent Agents against Multidrug-Resistant Mycobacterium tuberculosis

Tuberculosis (TB) is currently the leading cause of death related to infectious diseases worldwide, as reported by the World Health Organization. Moreover, the increasing number of multidrug-resistant tuberculosis (MDR-TB) cases has alarmed health agencies, warranting extensive efforts to discover novel drugs that are effective and also safe. In this study, 23 new compounds were synthesized and evaluated in vitro against the drug-resistant strains of M. tuberculosis. The compound 6-((3-fluoro-4-thiomorpholinophenyl)carbamoyl)benzo[c][1,2,5]oxadiazole 1-N-oxide (5 b) was particularly remarkable in this regard as it demonstrated MIC90 values below 0.28 μM against all the MDR strains evaluated, thus suggesting that this compound might have a different mechanism of action. Benzofuroxans are an attractive new class of anti-TB agents, exemplified by compound 5 b, with excellent potency against the replicating and drug-resistant strains of M. tuberculosis.

A method for the prevention or treatment of mycobacterial diseases

Disclosed in the present invention is a drug for preventing or treating mycobacterial diseases. In particular, disclosed is the use of a compound represented by the following general formula (I) or pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs thereof in preparing drugs for preventing or treating mycobacterial diseases, providing a new way for the prevention and treatment of tuberculosis and the like.

Preparation method of oxazolidinone compound

The invention provides a preparation method of an oxazolidinone compound, particularly relates to a novel preparation method of (S)-[N-3-(3-fluorine-4-(4-phenyl piperazinyl) phenyl)-2-oxo-5-oxazolidinyl] methylacetamide, and relates to the medical field. According to the existing preparation method, the reagent selection effect is non ideal, so that the existing preparation method is high in post-treatment operation difficulty, low in yield and unfavorable for industrial expansion. All the steps are improved; use of raw materials with relatively high toxicity is avoided, and better reagents and a treatment process which is easier to operate are selected; the product yield is greatly increased; the process is more stable and favorable for industrial production.

Synthesis of eperezolid-like molecules and evaluation of their antimicrobial activities

3-Fluoro-4-(4-phenylpiperazin-l-yl)aniline (II) prepared from 3,4-difluoro nitrobenzene was converted to the corresponding Schiff bases (III) and (IV) by treatment with 4-methoxybenzaldehyde and indol-3-carbaldehyde, respectively. Treatment of amine (II) with 4-fluorophenyl isothiocyanate afforded the corresponding thiourea derivative (V). Compound (V) was converted to thiazolidinone and thiazoline derivatives (VI) and (VII) by cyclocondensation with ethylbromoacetate or 4-chlorophenacylbromide, respectively. The synthesis of carbothioamide derivative (X) was performed starting from compound (II) by three steps. Treatment of compound (X) with sodium hydroxide, sulfuric acid, or chlorophenacyl bromide generated the corresponding 1,2,4-triazole (XI), 1,3,4-thiadiazole (XII), and 1,3-thiazolidinone (XIII) derivatives, respectively. The structural assignments of new compounds were based on their elemental analysis and spectral (IR, 1H-NMR, 13C-NMR, and LC-MS) data. In the antimicrobial activity study all the compounds revealed high anti-Mycobacterium smegmatis activity. Pleiades Publishing, Ltd., 2012.

CERTAIN CRYSTALLINE HYDRATES, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHODS FOR PREPARATION AND USE THEREOF

At least one crystalline hydrate of (S)-[N-3-(3'-fluoro-4'-(4''-phenyl piperazinyl)) phenyl-2-oxo-5-oxazolidinyl] methyl acetamide, such as those with the following formula, wherein y is a number ranging from 1/12 to 1. Also provided are methods for the preparation of such crystalline hydrates, pharmaceutical compositions comprising such crystalline hydrates, and methods for their uses.

Synthesis and antibacterial activity of linezolid analogues

Several new compounds of oxazolidinone class were designed and synthesized referring to the structure-activity relationship studies and the synthesis of Linezolid, and their antibacterial activity was studied.